BAG4 Antibody

Code CSB-PA000970
Size US$100
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  • Western Blot analysis of K562 cells using Bag-4 Polyclonal Antibody
  • Western Blot analysis of K562 cells using Bag-4 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
BAG4
Alternative Names
BAG 4 antibody; BAG family molecular chaperone regulator 4 antibody; BAG-4 antibody; BAG4 antibody; BAG4_HUMAN antibody; Bcl 2 associated athanogene 4 antibody; Bcl-2-associated athanogene 4 antibody; BCL2 associated athanogene 4 antibody; Silencer of death domains antibody; SODD antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the C-terminal region of Human Bag-4.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria.
Gene References into Functions
  1. AGS cells overexpressing BAG4 exhibited a significant increase in the percentage of cells in the G1/G0 peak and transfection of shRNA decrese demonstrated the opposite effect. PMID: 29067445
  2. acid-induced increase in SODD expression and decrease in cell apoptosis may depend on the activation of NOX5-S and NF-kappaB1 p50 in FLO cells PMID: 27756772
  3. SGK1.1 regulates gene transcription upon a different set of genes some of which participate in cell survival pathways (BAG-4) and others in intracellular vesicular traffic (Brox). PMID: 25849655
  4. SODD over-expression might be correlated with the clinical classification, curative effect, and prognosis of ALL cells. PMID: 24737427
  5. MicroRNA-26a is strongly downregulated in melanoma and induces cell death through repression of silencer of death domains (SODD). PMID: 23190898
  6. Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is responsible for radioresistance in human HT-R15 cells. PMID: 12017295
  7. SODD/BAG-4 is not only a silencer of TNFR1 but also a modulator of CD95 activity, regulating the balance of both death-promoting and -depressing signals PMID: 12706861
  8. BAG-4 functions as a negative regulator for apobec-1-mediated apoB mRNA editing PMID: 14559896
  9. Gene induces transformed phenotype when overexpressed in a cancer breast cell line. PMID: 17178857
  10. results of analysis of the genome-wide scan data was a 20 cM region at 8p11-23 in which markers had LODs > or =1.0. Linkage and association analyses of these SNPs yield suggestive results for markers in FGFR1 and BAG4. PMID: 17366557
  11. Vincristine induces Jurkat cell apoptosis by downregulating expression of SODD protein and priming the death receptor pathway. PMID: 17605853

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Subcellular Location
Cytoplasm.
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 940

OMIM: 603884

KEGG: hsa:9530

STRING: 9606.ENSP00000287322

UniGene: Hs.194726

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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