BATF3 Antibody, FITC conjugated

Datasheet

Code	CSB-PA882082LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) BATF3 Polyclonal antibody

Uniprot No.

Q9NR55

Target Names

BATF3

Alternative Names

BATF3 antibody; SNFTBasic leucine zipper transcriptional factor ATF-like 3 antibody; B-ATF-3 antibody; 21 kDa small nuclear factor isolated from T-cells antibody; Jun dimerization protein p21SNFT antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Basic leucine zipper transcriptional factor ATF-like 3 protein (2-65AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.

Gene References into Functions

The authors identified highly significant associations with better melanoma overall survival for rs6673928, impacting IL19 expression (HR, 0.56; 95% CI, 0.41-0.77; P = 0.0002) and rs6695772, controlling the expression of BATF3 (HR, 1.64; 95% CI, 1.19-2.24; P = 0.0019). PMID: 26733611
Basic Leucine Zipper ATF-Like Transcription Factor 3 (BATF3), an AP-1 family transcription factor, is a glucocorticoid receptor coregulator whose interaction with glucocorticoid receptor is modulated by the lever arm. PMID: 28708849
Batf3-dependent dendritic cells elicit the rejection of cells and grafts expressing mismatched minor histocompatibility antigens. PMID: 26034174
correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions PMID: 12087103
overexpression of p21SNFT in HepG2 cells leads to repression of matrix metalloproteinase-1 by 70-80% PMID: 15467742

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Subcellular Location

Nucleus.

Protein Families

BZIP family

Database Links

HGNC: 28915

OMIM: 612470

KEGG: hsa:55509

STRING: 9606.ENSP00000243440

UniGene: Hs.62919

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Related pathways

Target Therapy

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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