BATF3 Antibody

Code CSB-PA344549
Size US$100
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  • Western blot analysis of mouse-lung mouse-spleen lysis using BATF3 antibody. Antibody was diluted at 1:2000. Secondary antibody was diluted at 1:20000
  • Immunohistochemical analysis of paraffin-embedded human-breast-cancer, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-breast-cancer, antibody was diluted at 1:200
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Product Details

Uniprot No.
Target Names
BATF3
Alternative Names
BATF3 antibody; SNFTBasic leucine zipper transcriptional factor ATF-like 3 antibody; B-ATF-3 antibody; 21 kDa small nuclear factor isolated from T-cells antibody; Jun dimerization protein p21SNFT antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human BATF3.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.
Gene References into Functions
  1. The authors identified highly significant associations with better melanoma overall survival for rs6673928, impacting IL19 expression (HR, 0.56; 95% CI, 0.41-0.77; P = 0.0002) and rs6695772, controlling the expression of BATF3 (HR, 1.64; 95% CI, 1.19-2.24; P = 0.0019). PMID: 26733611
  2. Basic Leucine Zipper ATF-Like Transcription Factor 3 (BATF3), an AP-1 family transcription factor, is a glucocorticoid receptor coregulator whose interaction with glucocorticoid receptor is modulated by the lever arm. PMID: 28708849
  3. Batf3-dependent dendritic cells elicit the rejection of cells and grafts expressing mismatched minor histocompatibility antigens. PMID: 26034174
  4. correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions PMID: 12087103
  5. overexpression of p21SNFT in HepG2 cells leads to repression of matrix metalloproteinase-1 by 70-80% PMID: 15467742

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Subcellular Location
Nucleus.
Protein Families
BZIP family
Database Links

HGNC: 28915

OMIM: 612470

KEGG: hsa:55509

STRING: 9606.ENSP00000243440

UniGene: Hs.62919

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