BATF3 Antibody

Code CSB-PA344549
Size US$119
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  • Western blot analysis of mouse-lung mouse-spleen lysis using BATF3 antibody. Antibody was diluted at 1:2000. Secondary antibody was diluted at 1:20000
  • Immunohistochemical analysis of paraffin-embedded human-breast-cancer, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-breast-cancer, antibody was diluted at 1:200
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Product Details

Uniprot No.
Target Names
Alternative Names
BATF3 antibody; SNFTBasic leucine zipper transcriptional factor ATF-like 3 antibody; B-ATF-3 antibody; 21 kDa small nuclear factor isolated from T-cells antibody; Jun dimerization protein p21SNFT antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human BATF3.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Required for development of CD8-alpha(+) classical dendritic cells (cDCs) and related CD103(+) dendritic cells that cross-present antigens to CD8 T-cells and produce interleukin-12 (IL12) in response to pathogens. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.
Gene References into Functions
  1. The authors identified highly significant associations with better melanoma overall survival for rs6673928, impacting IL19 expression (HR, 0.56; 95% CI, 0.41-0.77; P = 0.0002) and rs6695772, controlling the expression of BATF3 (HR, 1.64; 95% CI, 1.19-2.24; P = 0.0019). PMID: 26733611
  2. Basic Leucine Zipper ATF-Like Transcription Factor 3 (BATF3), an AP-1 family transcription factor, is a glucocorticoid receptor coregulator whose interaction with glucocorticoid receptor is modulated by the lever arm. PMID: 28708849
  3. Batf3-dependent dendritic cells elicit the rejection of cells and grafts expressing mismatched minor histocompatibility antigens. PMID: 26034174
  4. correlation of transcriptional repression by p21(SNFT) with changes in DNA.NF-AT complex interactions PMID: 12087103
  5. overexpression of p21SNFT in HepG2 cells leads to repression of matrix metalloproteinase-1 by 70-80% PMID: 15467742

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Subcellular Location
Nucleus.
Protein Families
BZIP family
Database Links

HGNC: 28915

OMIM: 612470

KEGG: hsa:55509

STRING: 9606.ENSP00000243440

UniGene: Hs.62919

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