BIRC8 Antibody

Code CSB-PA846680ESR2HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) BIRC8 Polyclonal antibody
Uniprot No.
Target Names
BIRC8
Alternative Names
Baculoviral IAP repeat containing 8 antibody; Baculoviral IAP repeat containing protein 8 antibody; Baculoviral IAP repeat-containing protein 8 antibody; BIRC 8 antibody; BIRC8 antibody; BIRC8 protein antibody; BIRC8_HUMAN antibody; hILP 2 antibody; hILP2 antibody; IAP like protein 2 antibody; IAP-like protein 2 antibody; ILP 2 antibody; ILP-2 antibody; Inhibitor of apoptosis like protein 2 antibody; Inhibitor of apoptosis-like protein 2 antibody; Testis specific inhibitor of apoptosis antibody; Testis-specific inhibitor of apoptosis antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Baculoviral IAP repeat-containing protein 8 protein (1-236AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Protects against apoptosis mediated by BAX.
Gene References into Functions
  1. High ILP-2 expression is associated with breast cancer. PMID: 30106449
  2. Fumonisin B1 caused dose-dependent increase in BIRC-8/ILP-2 mRNA and protein expression in HepG2 cells to inhibit apoptosis. PMID: 25800559
  3. results indicate that ILP-2 is a novel breast cancer biomarker in the peripheral blood. PMID: 23222679
  4. increased expression with progression of chronic myeloid leukaemia PMID: 24266799
  5. role in preventing shear-stress induced endothelial cell apoptosis via negative regulation of caspase-3 PMID: 12372615
  6. ILP2 is an unstable protein, and cannot inhibit caspase 9 in a physiological way on its own; possibly ILP2 requires assistance from unidentified cellular factors to be an effective inhibitor of apoptosis in vivo PMID: 15485395

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Subcellular Location
Cytoplasm.
Protein Families
IAP family
Tissue Specificity
Testis specific in normal tissues.
Database Links

HGNC: 14878

KEGG: hsa:112401

STRING: 9606.ENSP00000412957

UniGene: Hs.348263

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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