CA3 Antibody

Code CSB-PA004371GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
CA3
Alternative Names
CA III antibody; CA-III antibody; Ca3 antibody; CAH3_HUMAN antibody; CAIII antibody; Car3 antibody; Carbonate dehydratase III antibody; Carbonic anhydrase 3 antibody; Carbonic anhydrase III antibody; Carbonic anhydrase III muscle specific antibody; EC 4.2.1.1 antibody; Epididymis secretory sperm binding protein Li 167mP antibody; HEL S 167mP antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human CA3
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Reversible hydration of carbon dioxide.
Gene References into Functions
  1. CAIII and Hsp70 expressions were higher in LPRD patients that in non-LPRD patients, suggesting the possibility as one of biomomarker in LPRD diagnosis. PMID: 26847302
  2. this study detected the formation and colocalization of 6-nitrotryptophan-containing proteins and CAIII in the skin of atopic dermatitis patients, not only in the lesional part but also in the nonlesional part, through histochemical analyses PMID: 24838180
  3. Report that anti-CAIII antibodies may be useful for diagnosing microscopic polyangiitis. PMID: 23981757
  4. The carbonic anhydrase CA3 isoform displayed an increased abundance during muscle aging, which was independently verified by immunoblotting of differently aged human skeletal muscle samples. PMID: 22797148
  5. The generation of CA III and IV autoantibodies, antioxidant enzymes, and cytokines might influence each other. PMID: 23049597
  6. Crystallization and preliminary X-ray analysis of human carbonic anhydrase III PMID: 11976500
  7. Data show that inserting histidine residues into the active site cavity of carbonic anhydrase II or III results in rates of proton transfer to the zinc-bound hydroxide that are antagonistic or suppressive with respect to the corresponding single mutants. PMID: 12171926
  8. Proton transfer within the active-site cavity of carbonic anhydrase III PMID: 12484342
  9. myoglobin/carbonic anhydrase III ratio in the blood proved to be a more specific indicator for myocardial damage than myoglobin alone after myocardial infarction. PMID: 12745799
  10. CAIII expression is upregulated in kidney cortex samples from the end-stage kidney of a patient with Dent's disease owing to the G506E mutation of CLCN5 PMID: 18322545
  11. CAIII promotes transformation and invasion capability in hepatoma cells through FAK signaling pathway. PMID: 18444244
  12. The level of CAIII is specifically insufficient in the skeletal muscle of myasthenia gravis patients. PMID: 19301202

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Subcellular Location
Cytoplasm.
Protein Families
Alpha-carbonic anhydrase family
Tissue Specificity
Muscle specific.
Database Links

HGNC: 1374

OMIM: 114750

KEGG: hsa:761

STRING: 9606.ENSP00000285381

UniGene: Hs.82129

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