CACNA1H Antibody

Datasheet
Code CSB-PA154566
Product Type Polyclonal Antibody
Size US$297
Uniprot No. O95180
Image
  • Western blot analysis of extracts from A549 cells, using CACNA1H antibody.
Immunogen Synthesized peptide derived from internal of Human CACNA1H.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Specificity The antibody detects endogenous levels of total CACNA1H protein.
Tested Applications ELISA,WB;WB:1:500-1:3000
Relevance Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1Hgives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

Cribbs L.L., Circ. Res. 83:103-109(1998).
Cribbs L.L., Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Williams M.E., J. Neurochem. 72:791-799(1999).
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Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality Polyclonal
Alias CAC1H; CACNA1HB; calcium channel; voltage-dependent; alpha 1H subunit
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Target Names CACNA1H
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia
Involvement in disease Epilepsy, idiopathic generalized 6 (EIG6); Epilepsy, childhood absence 6 (ECA6); Hyperaldosteronism, familial, 4 (HALD4)
Subcellular Location Membrane, Multi-pass membrane protein
Protein Families Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1H subfamily
Tissue Specificity In nonneuronal tissues, the highest expression levels are found in the kidney, liver, and heart. In the brain, most abundant in the amygdala, caudate nucleus, and putamen (PubMed:9670923, PubMed:9930755). In the heart, expressed in blood vessels. Isoform
Database Links

HGNC: 1395

OMIM: 607904

KEGG: hsa:8912

STRING: 9606.ENSP00000334198

UniGene: Hs.459642

Pathway Calcium signaling pathway
MAPK signaling pathway

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