CACNA1H Antibody

Code CSB-PA004342
Size US$167
Uniprot No. O95180
  • Western Blot analysis of A549 cells using T-type Ca++ CP α1H Polyclonal Antibody
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Immunogen Synthesized peptide derived from the Internal region of Human T-type Ca++ CP α1H.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications WB,ELISA;WB:1/500-1/2000.ELISA:1/10000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias CACNA1H; Voltage-dependent T-type calcium channel subunit alpha-1H; Low-voltage-activated calcium channel alpha1 3.2 subunit; Voltage-gated calcium channel subunit alpha Cav3.2
Immunogen Species Homo sapiens (Human)
Target Names CACNA1H
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia
Involvement in disease Epilepsy, idiopathic generalized 6 (EIG6); Epilepsy, childhood absence 6 (ECA6); Hyperaldosteronism, familial, 4 (HALD4)
Subcellular Location Membrane, Multi-pass membrane protein
Protein Families Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1H subfamily
Tissue Specificity In nonneuronal tissues, the highest expression levels are found in the kidney, liver, and heart. In the brain, most abundant in the amygdala, caudate nucleus, and putamen (PubMed:9670923, PubMed:9930755). In the heart, expressed in blood vessels. Isoform
Database Links

HGNC: 1395

OMIM: 607904

KEGG: hsa:8912

STRING: 9606.ENSP00000334198

UniGene: Hs.459642

Pathway Calcium signaling pathway
MAPK signaling pathway

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