CALR Antibody

Code CSB-PA004458YA01PI
Size US$299
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Product Details

Full Product Name Rabbit anti-Sus scrofa (Pig) CALR Polyclonal antibody
Uniprot No. P28491
Target Names CALR
Alternative Names CALRCalreticulin antibody; CRP55 antibody; Calregulin antibody; Endoplasmic reticulum resident protein 60 antibody; ERp60 antibody; HACBP antibody
Raised in Rabbit
Species Reactivity Pig
Immunogen Recombinant Pig Calreticulin protein (18-417AA)
Immunogen Species Sus scrofa (Pig)
Conjugate Non-conjugated

The CALR Antibody (Product code: CSB-PA004458YA01PI) is Non-conjugated. For CALR Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA004458YB01PI CALR Antibody, HRP conjugated ELISA
FITC CSB-PA004458YC01PI CALR Antibody, FITC conjugated
Biotin CSB-PA004458YD01PI CALR Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy.
Gene References into Functions
  1. Here the authors identify porcine calreticulin expressed by swine intestinal cells as a host-specific receptor for Salmonella Choleraesuis FimH adhesin, suggesting that such an interaction may contribute to Salmonella Choleraesuis host specificity. PMID: 28770174
  2. Calreticulin is confined to subplasmalemmal vesicles partially overlapping with cortical granule contents. Its exocytosis after the oocyte activation seems to participate in the membrane block to polyspermy in pigs. PMID: 24398873
  3. Calreticulin was widely expressed in pig tissues and its transcripts were downregulated during maturation, especially at 44 hr, and were undetectable at the blastocyst stage. PMID: 20222029
Subcellular Location Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen. Cytoplasmic vesicle, secretory vesicle, Cortical granule. Cytolytic granule.
Protein Families Calreticulin family
Tissue Specificity In blastocyst expressed in all blastomeres (at protein level). In embryos, expressed in spleen, kidney, liver, fat, muscle, ovary, granulosa cells and cumulus cells.
Database Links

KEGG: ssc:100381266

STRING: 9823.ENSSSCP00000014615

UniGene: Ssc.48945

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