CCHCR1 Antibody

Datasheet

Code	CSB-PA004769LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: 293T whole cell lysate, 293 whole cell lysate, HepG2 whole cell lysate, THP-1 whole cell lysate, U251 whole cell lysate All lanes: CCHCR1 antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 89, 100, 96 kDa Observed band size: 89 kDa IHC image of CSB-PA004769LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Immunofluorescence staining of U251 cells with CSB-PA004769LA01HU-IF at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CCHCR1 Polyclonal antibody

Uniprot No.

Q8TD31

Target Names

CCHCR1

Alternative Names

Coiled-coil alpha-helical rod protein 1 (Alpha-helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8), CCHCR1, C6orf18 HCR

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Coiled-coil alpha-helical rod protein 1 protein (281-500aa)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CCHCR1 Antibody (Product code: CSB-PA004769LA01HU) is Non-conjugated. For CCHCR1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA004769LB01HU	CCHCR1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA004769LC01HU	CCHCR1 Antibody, FITC conjugated
Biotin	CSB-PA004769LD01HU	CCHCR1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:100-1:500
IF	1:100-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May be a regulator of keratinocyte proliferation or differentiation.

Gene References into Functions

psoriasis candidate gene CCHCR1 expressed at P-bodies and centrosomes PMID: 29866042
CCHCR1 interacts specifically with the E2 protein of human papillomavirus type 16 on a surface overlapping BRD4 binding PMID: 24664238
Confocal imaging confirmed the localization of CCHCR1 in P-bodies. PMID: 24858563
The centrosomal localization of CCHCR1 provides a connection to the abnormal cell proliferation and offers a link to possible cellular pathways altered in psoriasis. PMID: 23189171
Psoriasis is associated with genetic polymorphism in the CCHCR1 gene and in a genomic segment flanking the HLA-C region in the North Indian population. PMID: 22182809
Isolated by a two hybrid assay, StAR binding protein binds StAR protein in cells and enhances the ability of StAR protein to promote syntheses of steroid hormones.(sTAR binding protein) PMID: 12909641
These studies show that miR-122, a 22-nucleotide microRNA, is derived from a liver-specific noncoding polyadenylated RNA transcribed from the gene hcr. PMID: 17179747
These results suggest a role for CCHCR1 in the pathogenesis of psoriasis via the regulation of skin steroid metabolism. PMID: 17221218
Results show that HLA-Cw6 and CCHCR1 risk allele associations with clinical features of psoriasis are predictably highly similar in a Finnish nationwide cohort of 379 psoriasis patients. PMID: 17340018
the aberrant function of CCHCR1 may lead to abnormal keratinocyte proliferation which is a key feature of psoriatic epidermis. PMID: 18174193
CCHCR1 is up-regulated in skin cancer and associated with EGFR expression PMID: 19551138

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Subcellular Location

Cytoplasm. Nucleus.

Tissue Specificity

Found in all tissues tested, abundantly expressed in heart, liver, skeletal muscle, kidney and pancreas, and to a lesser extent in lung and placenta. Overexpressed in keratinocytes of psoriatic lesions.

Database Links

HGNC: 13930

OMIM: 605310

KEGG: hsa:54535

STRING: 9606.ENSP00000379566

UniGene: Hs.485075

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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