CCRL2 Antibody

Code CSB-PA004852LA01HU
Size US$299
  • Western Blot
    Positive WB detected in: HL60 whole cell lysate
    All lanes: CCRL2 antibody at 2.5µg/ml
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 40, 41 kDa
    Observed band size: 40 kDa

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA004852LA01HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CCRL2 Polyclonal antibody
Uniprot No. O00421
Target Names CCRL2
Alternative Names
CCRL2; CCR11; CCR6; CKRX; CRAM; HCR; C-C chemokine receptor-like 2; Chemokine receptor CCR11; Chemokine receptor X; Putative MCP-1 chemokine receptor
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human C-C chemokine receptor-like 2 protein (1-43AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The CCRL2 Antibody (Product code: CSB-PA004852LA01HU) is Non-conjugated. For CCRL2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA004852LB01HU CCRL2 Antibody, HRP conjugated ELISA
FITC CSB-PA004852LC01HU CCRL2 Antibody, FITC conjugated
Biotin CSB-PA004852LD01HU CCRL2 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
Gene References into Functions
  1. CCRL2 mRNA was not significantly changed in murine and human non-alcoholic steatohepatitis liver. CCRL2 mRNA levels were positively correlated with inflammation, fibrosis and NASH scores in the patients. PMID: 28600126
  2. CCRL2 inhibited the growth of breast cancer cells in vitro and in vivo. PMID: 26487662
  3. in breast cancer, CRAM-A becomes specifically upregulated under inflammatory stimuli and may serve as a potential marker of immune response. PMID: 26563945
  4. these results suggest for the first time that elevated CCRL2 in glioma promotes cell migration and invasion. PMID: 23142225
  5. Considering the newly defined role of CCRL2 in lung dendritic cell trafficking, this atypical chemokine receptor may affect pneumocystis pneumonia through immune regulation and inducing inflammation. PMID: 22046140
  6. demonstration that the homeostatic chemokine CCL19 is a specific ligand for CRAM PMID: 20002784
  7. CCRL2 expression is up-regulated on synovial neutrophils of rheumatoid arthritis patients PMID: 15188357
  8. Results identify chemerin as a natural nonsignaling protein ligand for both human and mouse CCRL2. PMID: 18794339

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Subcellular Location Cell membrane; Multi-pass membrane protein.
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), mo
Database Links

HGNC: 1612

OMIM: 608379

KEGG: hsa:9034

STRING: 9606.ENSP00000349967

UniGene: Hs.535713

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