CCT5 Antibody

Datasheet

Code	CSB-PA004862EA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, HepG2 whole cell lysate All lanes: CCT5 antibody at 4µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 60, 50 kDa Observed band size: 60 kDa Immunofluorescence staining of A549 cells with CSB-PA004862EA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CCT5 Polyclonal antibody

Uniprot No.

P48643

Target Names

CCT5

Alternative Names

CCT 5 antibody; CCT epsilon antibody; CCT-epsilon antibody; CCT5 antibody; CCTE antibody; CCTepsilon antibody; Chaperonin containing T-complex polypeptide 1; subunit 5 antibody; Chaperonin containing TCP 1 epsilon antibody; Chaperonin containing TCP 1 subunit 5 antibody; Chaperonin containing TCP 1 subunit 5 epsilon antibody; Chaperonin containing TCP1 epsilon antibody; Chaperonin containing TCP1 subunit 5 antibody; Chaperonin containing TCP1 subunit 5 epsilon antibody; KIAA0098 antibody; T complex protein 1 epsilon subunit antibody; T complex protein 1 subunit epsilon antibody; T-complex protein 1 subunit epsilon antibody; TCP 1 epsilon antibody; TCP-1-epsilon antibody; TCP1epsilon antibody; TCPE antibody; TCPE_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human T-complex protein 1 subunit epsilon protein (1-270AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CCT5 Antibody (Product code: CSB-PA004862EA01HU) is Non-conjugated. For CCT5 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA004862EB01HU	CCT5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA004862EC01HU	CCT5 Antibody, FITC conjugated
Biotin	CSB-PA004862ED01HU	CCT5 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.

Gene References into Functions

CCT5 complex caps mutant mHTT fibrils at their tips and encapsulates mHTT oligomers, providing a structural description of the inhibition of mHTTQ46-Ex1 by CCT5 complex and a shared mechanism of mHTT inhibition between TRiC chaperonin and the CCT5 complex PMID: 25995452
H147R CCT5 was not as efficient in chaperoning these substrates as wild type CCT5. PMID: 25124038
introduction of the truncated human CCT epsilon subunit into yeast cells PMID: 22232265
A missense mutation within the CCT5 gene is associated with autosomal recessive mutilating sensory neuropathy with spastic paraplegia. PMID: 16399879

Involvement in disease

Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive (HSNSP)

Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Protein Families

TCP-1 chaperonin family

Database Links

HGNC: 1618

OMIM: 256840

KEGG: hsa:22948

STRING: 9606.ENSP00000280326

UniGene: Hs.1600

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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