CCT6A Antibody

Code CSB-PA004865ESR1HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA004865ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA004865ESR1HU at dilution of 1:100

  • Immunoprecipitating CCT6A in Hela whole cell lysate
    Lane 1: Rabbit control IgG instead of CSB-PA004865ESR1HU in Hela whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
    Lane 2: CSB-PA004865ESR1HU (8μg) + Hela whole cell lysate (500μg)
    Lane 3: Hela whole cell lysate (10μg)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CCT6A Polyclonal antibody
Uniprot No.
Target Names
CCT6A
Alternative Names
CCT6A antibody; CCT6 antibody; CCTZ antibody; T-complex protein 1 subunit zeta antibody; TCP-1-zeta antibody; Acute morphine dependence-related protein 2 antibody; CCT-zeta-1 antibody; HTR3 antibody; Tcp20 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human T-complex protein 1 subunit zeta protein (80-250AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC, IP
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IP 1:200-1:2000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Gene References into Functions
  1. High expression of CCT6A is associated with Non-Small Cell Lung Cancer. PMID: 28104536
  2. selective inhibition of SMAD3 or CCT6A efficiently suppresses TGF-beta-mediated metastasis. Findings provide a mechanism that directs TGF-beta signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta for non-small-cell lung carcinoma. PMID: 28375158
  3. These data suggest that CCT6A is a novel autoantigen recognized by Vdelta2 gammadelta T cells, which deepens our understanding of mechanisms in autoimmune diseases. PMID: 27489109
  4. identified genes, which include Tcp20, may play important role in conferring radioresistance to oral squamous cell carcinoma and could be useful in identifying cases with more radioresistance PMID: 16211299
Subcellular Location
Cytoplasm.
Protein Families
TCP-1 chaperonin family
Database Links

HGNC: 1620

OMIM: 104613

KEGG: hsa:908

STRING: 9606.ENSP00000275603

UniGene: Hs.82916

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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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