CD36 Antibody

Code CSB-PA004927GA01HU
Size US$685
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Product Details

Uniprot No. P16671
Target Names CD36
Alternative Names Adipocyte membrane protein antibody; BDPLT10 antibody; CD36 antibody; CD36 antigen (collagen type I receptor, thrombospondin receptor) antibody; CD36 antigen antibody; CD36 molecule (thrombospondin receptor) antibody; CD36 molecule antibody; CD36_HUMAN antibody; CHDS7 antibody; Cluster determinant 36 antibody; Collagen receptor, platelet antibody; FAT antibody; Fatty acid translocase antibody; Fatty acid transport protein antibody; Glycoprotein IIIb antibody; GP IIIb antibody; GP3B antibody; GP4 antibody; GPIIIB antibody; GPIV antibody; Leukocyte differentiation antigen CD36 antibody; MGC108510 antibody; MGC91634 antibody; PAS 4 protein antibody; PAS IV antibody; PAS-4 antibody; PASIV antibody; Platelet collagen receptor antibody; Platelet glycoprotein 4 antibody; Platelet glycoprotein IV antibody; scarb3 antibody; Scavenger receptor class B member 3 antibody; SR-B3 antibody; SRB3 antibody; Thrombospondin receptor antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Human CD36
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles.
Form Liquid
Tested Applications ELISA,IHC
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity)
Gene References into Functions
  1. normal and defective embryos lacking SR-B1 have divergent expression profiles PMID: 30290792
  2. CD36 plays an important role in the preabsorptive hormone and Bile acids responses that coordinate brain and gut regulation of energy metabolism. PMID: 29546316
  3. We identified CD36 as one of the most significantly upregulated lipid-related genes in senescent cells. We showed that overexpression of CD36 in proliferating cells resulted in a senescence-like phenotype. We hypothesize that CD36 overexpression leads to changes in membrane remodeling and plausibly mediate SASP release. PMID: 29974107
  4. Our findings indicated that hepatic stellate cells-derived COMP collaborated with CD36 and subsequently played an essential role in MEK/ERK and PI3K/AKT-mediated hepatocellular carcinoma (HCC) progression. COMP might act as a promising target for the diagnosis and treatment of aggressive HCC. PMID: 30231922
  5. Study shows the CD36 expression level downregulated in the lung cancer. Further, results found that the high methylation of CD36 corresponding to its low expression in lung cancer played an important role in the procession of lung cancer. PMID: 29969695
  6. The rs7755 and rs3211956 loci polymorphisms of CD36 gene and genotype E2/E3, E3/E4, E4/E4 of ApoE gene, and E2 and E4 alleles were statistically related with Alzheimer disease. PMID: 30235742
  7. This study suggests that T2D patients with different genotypes at CD36, NOS3 and PPARG respond differentially to intervention of omega-3 supplements in blood lipid profiles. PMID: 29703528
  8. Gene expressions of YKL-40 and CD36 were significantly higher in patients with T2DM (>5 yr) with hypertension compared to healthy controls (P=0.006). In addition, a significant increase in serum levels of sCD36, PPAR-gamma and YKL-40 was observed in patients with T2DM (>5 yr) with hypertension compared to healthy controls PMID: 29806605
  9. genetic association studies in population of preschool-aged children in Guelph, Ontario: Data suggest that SNPs in CD36 (rs1761667), TAS1R2 (rs35874116), and TAS2R38 (rs713598) are associated with snacking behavior in the population studied. [PILOT PROJECTS] PMID: 29385734
  10. CD36 is important for muscle glucose metabolism and optimal insulin responsiveness. PMID: 29748289
  11. Significant up-regulation of PBMCs CAP1, CD36 mRNA and plasma resistin found in significant coronary artery disease, as well as in nonsignificant coronary artery disease compared to control group, indicates that resistin could be able to exert its effects stronger on cells with up-regulated CAP1 mRNA thus contributing atherosclerosis development. PMID: 28707728
  12. CD36, also known as FA translocase (FAT), that functions as a transmembrane protein and mediates the uptake of FAs, is observed to be highly expressed in breast cancer tissues. Furthermore, the anti-proliferation effect caused by the SCD1 inhibitor can not be reversed by exogenous oleic acid supplementation in CD36 knockdown breast cancer cells PMID: 28765876
  13. Results showed that CD36 genotypes were not associated with the progression to T2DM independently. however, the study suggested a positive interaction between the CD36 variants and obesity on T2DM susceptibility, which might be through a cardiometabolic disorder. PMID: 29572193
  14. Taken together, these findings indicate that rs1194182 polymorphism in the CD36 gene was associated with intracerebral hemorrhage, and genotype GG could be an independent predictor. PMID: 28804718
  15. Three polymorphisms were found to be associated with increases in IOP: rs1049673 (p = 0.006), rs3211931 (p = 0.01), and rs1761667 (p = 0.043) at the time of the third injection only. PMID: 28557591
  16. CD36 marks adipocyte progenitor cells with pronounced adipogenic potential, most probably by facilitating lipid uptake. PMID: 28470788
  17. sCD36 levels increased with the level of intrahepatic lipid, insulin resistance and dyslipidemia; association with markers of obesity and the association with hepatic CD36 mRNA expression suggest that excess sCD36 in NAFLD patients is derived from the hepatocytes, which may support that CD36 is involved in NAFLD development; an unhealthy CD36 expression in adipose and hepatic tissue may shift the fatty-acid load to liver PMID: 27916988
  18. In conclusion, oxLDL induced MALAT1 transcription and MALAT1 recruits beta-catenin to binding sites on the CD36 promoter to induce CD36 expression, which enhances lipid uptake in macrophages. PMID: 29258822
  19. Based on these findings, we conclude that an acetylation-deacetylation signaling step might regulate CD36 functional activity and subsequent lipid accumulation and caspase 3 activation in pancreatic beta cells exposed to GLT conditions. PMID: 29274335
  20. These results indicated that AKT-PPARgamma signaling pathway mediated HG-induced lipid deposition by upregulating CD36 expression in HK-2 cells and that inhibition of AKT-PPARgamma signaling pathway had the potential beneficial effects of reducing lipid deposition in diabetic kidney. PMID: 28497039
  21. CD36/STAT3 SNPs linked to cardiovascular disease may modulate the effects of different diets on biochemical and inflammatory markers among these subjects. PMID: 27596284
  22. These data show the potential pleiotropic influence of CD36 SNP rs1984112 on lipoprotein accumulation in a young healthy cohort. PMID: 27460265
  23. S100A12 binds to CD36 in the low nanomolar range at the CD36 thrombospondin-1 binding site. PMID: 27734162
  24. The inhibition of Rac1 by NSC23766 inhibited NADPH oxidase activity and ROS generation induced by high glucose concentrations in INS-1 & human 1.1b4 beta cells. Inhibition of Rac1-NOX complex activation by NSC23766 significantly reduced CD36 expression in INS-1 and human 1.1b4 beta cell membrane fractions. PMID: 27912197
  25. Review of the regulation and post-translational modification of CD36 and its role in renal pathophysiology and chronic kidney disease. PMID: 28919632
  26. The A allele of the rs1761667 single nucleotide polymorphism in CD36 is associated with decreased fat and sugar intake in obese children and adolescents. PMID: 28237985
  27. The present study concluded that miR-758-5p decreases lipid accumulation of foam cell via regulating CD36-mediated cholesterol uptake. PMID: 28965954
  28. Data show that all the six inflammation-related CpG-SNPs genotypes including IL1B rs16944, IL1R2 rs2071008, PLA2G7 rs9395208, FAM5C rs12732361, CD40 rs1800686, and CD36 rs2065666 were associated with coronary heart disease (CHD), suggesting an important role of inflammation in the risk of CHD. PMID: 27461004
  29. CD36 single nucleotide polymorphisms rs1194182 and rs10499859 reduce risk to pulmonary tuberculosis in a Chinese Han population. PMID: 28693442
  30. CD36 and MARCO are associated with the susceptibility of Chinese Han females to carotid atherosclerosis. Menopausal status may affect the association between gene polymorphisms and carotid atherosclerosis in the female Chinese Han population. PMID: 28866086
  31. this study shows that diet-induced obesity links to estrogen receptor-positive breast cancer progression via LPA/PKD-1-CD36 signaling-mediated microvascular remodeling PMID: 28186980
  32. These findings suggest that atherogenic conditions critically regulate platelet CD36 signaling by increasing superoxide radical anion and hydrogen peroxide through a mechanism that promotes activation of MAPK ERK5. PMID: 28336528
  33. High CD36 expression is associated with Acute Monocytic Leukemia. PMID: 28108519
  34. Common CD36 SNPs reduce adipose and heart CD36 levels to higher chylomicron remnants and LDL in humans. PMID: 27729386
  35. this studies provide evidence that CD36 mediates surfactant lipid uptake by human macrophages and that Mycobacterium tuberculosis exploits this function for growth PMID: 27913648
  36. a substantial fraction of unligated CD36 exists in nanoclusters, which not only promote TSP-1 binding but are also enriched with the downstream effector Fyn. PMID: 27694211
  37. Influence of a common genetic variant in CD36 on susceptibility to endothelial dysfunction and its response to sildenafil treatment. PMID: 27144937
  38. This study supports the notion that CD36 - specifically rs1527483, plays a role in oral fat perception, but not in influencing obesity in Malaysian subjects. PMID: 27847178
  39. Lysophosphatidic acid/PKD-1 signaling leads to nuclear accumulation of histone deacetylase 7, where it interacts with forkhead box protein O1 to suppress endothelial CD36 transcription and mediates silencing of antiangiogenic switch, resulting in proangiogenic and proarteriogenic reprogramming. PMID: 27013613
  40. Individuals >/=30 years old with abdominal obesity presented lower CD36 levels, and lower subexpression of CD36 mRNA compared to individuals <30 years old with abdominal obesity. PMID: 27525284
  41. molecular dynamics (MD) simulation studies demonstrated that CD36 TM1 exhibited a switching dimerization with two right-handed packing modes driven by the (12)GXXXGXXXA(20) and (20)AXXG(23) motifs, and the mutational effect of G16I and G23I revealed these representative conformations of CD36 TM1. PMID: 28336533
  42. study demonstrates that tamoxifen inhibits CD36 expression and cellular oxLDL accumulation by inactivating the PPARgamma signaling pathway, and the inhibition of macrophage CD36 expression can be attributed to the anti-atherogenic properties of tamoxifen. PMID: 27358406
  43. This review focuses on recent advances on the role of these signaling pathways and transcription factors involved in the regulation of CD36 and GLUT4. PMID: 27403883
  44. Chromatin immunoprecipitation analysis revealed that Rspo2 manipulation led to regulation of the direct binding between PPARgamma and CD36. PMID: 27571704
  45. description of a subpopulation of CD44(bright) cells in human oral carcinomas that do not overexpress mesenchymal genes, are slow-cycling, express high levels of the fatty acid receptor CD36 and lipid metabolism genes, and are unique in their ability to initiate metastasis PMID: 27974793
  46. Our results are similar to those found in Portuguese population which reported the role of rs1984112_G in increasing reticulocyte level among SCD patients. Consequently, the rs1984112_G of CD36 could be considered as a reliable biomarker for predicting patients at high risk for vascular occlusions and thus, allows earlier and more effective therapeutic management. PMID: 27869039
  47. The SNP rs3211892 has previously been associated with heart disease and other conditions but the present study is the first to identify a significant association between variations in CD36 gene and the risk of Alzheimer's disease. PMID: 28111291
  48. the results demonstrate that a novel CD36-ERK/MAPK-dependent mechanism is involved in macrophage lipid accumulation by piHDL, there by revealing the importance of functional deficiency in HDL and its potential link to atherogenesis. PMID: 27995417
  49. The findings reveal previously unknown pro-thrombotic activities of oxidized plasma albumin via a CD36 dependent pathway in end-stage kidney disease patients. PMID: 26905525
  50. no association between placental expression and maternal body mass index PMID: 27016784
  51. CD36 is a co-receptor for hepatitis C virus E1 protein attachment. PMID: 26898231
  52. Training response at both SNPs identified "at-risk" genotypes responding favourably to the training stimulus in fat oxidation, triglyceride (TG) levels, diastolic blood pressure, and mean arterial pressure. PMID: 26830498
  53. Six CD36 genetic variants were identified, two of them were novel, all but one are found exclusively in CD36(null) and CD36(low) expressors and displayed deficient or reduced CD36 on monocytes. PMID: 26528880
  54. we propose that VPA may enhance OLA-induced hepatocyte steatosis through the upregulation of PPARg and CD36-dependent lipid uptake, TAG synthesis, and lipid droplet formation. PMID: 27034954
  55. Tissue factor uptake by platelets involves the scavenger receptor CD36, SERT and engages PI3-Kinase activation and cytoskeletal assembly. PMID: 26221761
  56. Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma PMID: 26424075
  57. We report that rs1761667 polymorphism of CD36 gene and oro-gustatory thresholds for fat might play a significant role in the development of obesity in young teenagers. PMID: 26556365
  58. Identify a CD36-mediated mechanistic pathway through which extracellular vesicles inhibit microvascular endothelial cell migration and tube formation. PMID: 26821945
  59. Nrf2-driven CD36 and HO-1 expression on innate immune cells could contribute to a protective and detoxifying mechanism during pregnancy-associated malaria. PMID: 26385579
  60. Taken together, our study suggests that aging facilitates lesion development in apoE(-/-) mice with greater effect on male mice. PMID: 26592663
  61. CD36 SNP A-allele, being present both in young lean and in obese children, is associated with high threshold for fatty acid taste sensitivity only in obese children. PMID: 25687220
  62. these results demonstrate that an interaction between STAT1, p300, and peroxisome proliferator-activated receptor-gamma is required for 15(S)-HETE-induced CD36 expression, oxidized low density lipoprotein uptake, and foam cell formation PMID: 26504087
  63. Novel methylation variation within CD36 strongly correlated to plasma triglyceride and HDL-cholesterol. PMID: 26021296
  64. We identified SR-BI to indicate human prostate cancer formation, suggesting that increased levels of SR-BI may be involved in the generation of a castration-resistant phenotype. PMID: 26251134
  65. The presented data suggest possible protective effects of higher soluble CD36 concentration in relation to metabolic syndrome components in coronary artery disease patients. PMID: 25916834
  66. PCSK9-mediated CD36 degradation may serve to limit fatty acid uptake and triglyceride accumulation in tissues, such as the liver and adipose tissue. PMID: 26494228
  67. These data suggest that inhibition of CD36 prevented high glucose - induced epithelial-to-mesenchymal transition in renal tubular epithelial cells, highlighting CD36 as a potential therapeutic target for diabetic nephropathy. PMID: 26505798
  68. Eleven SNPs in the CD36 gene and their association with 100 each of control subjects and T2DM patients were investigated in the present study. PMID: 25565374
  69. Micelles mimicking physiological structures were necessary for optimal binding to both the extracellular loop of CD36 (lCD36) and the extracellular loop of SR-BI (lSR-BI). PMID: 25833688
  70. A plausible prognostic/adjuvant biomarker role of soluble CD36 for diabetic nephropathy. PMID: 25619588
  71. Heterozygous CD36 mutations, previously known to lead to deficiency in this molecule, are one of the factors responsible for the diversity of CD36 surface expression levels on platelets and monocytes in normal phenotype subjects. PMID: 25798958
  72. Data suggest that components of dietary fat (long-chain fatty acids) act as ligands for fatty acid translocase/CD36 and participate in regulation of intestinal absorption and the satiety response. [REVIEW] PMID: 26269236
  73. CD36 genotype was associated with fat oxidation during sub-maximal exercise, resting heart rate and blood pressure, indicating increased chronic disease risk in an otherwise healthy cohort. PMID: 25277110
  74. Genetic variation in human fatty acid transporter CD36 can have effects on regulation of energy homeostasis. PMID: 25723554
  75. results showed a direct association between orosensory perception of oleic acid and PROP tasting or rs1761667 polymorphism of CD36, which play a significant role in PROP non-tasters, given their low number of taste papillae. PMID: 25803547
  76. Platelet-derived exosomes inhibit athero-thrombotic processes by reducing CD36-dependent lipid loading of macrophages and by suppressing platelet thrombosis. Exosomes increase protein ubiquitination and enhance proteasome degradation of CD36. PMID: 25163645
  77. Data (including data from studies using recombinant proteins) suggest that a diverse range of ligands activate platelets through activation/phosphorylation of CD36/GPVI (glycoprotein VI) and/or CLEC-2 (C-type lectin-like receptor-2). PMID: 25849538
  78. CD36 SNP 1761667 may have a role in decreased lipid taste perception in obese Tunisian women PMID: 25822988
  79. The distribution of CD36 gene variants in the Chinese population is different from that previously reported. The levels of expression of CD36 antigen in platelets are not determined directly by the genotypes of the CD36 coding region. PMID: 24960640
  80. Unconditional logistic regression analysis showed that gender, diabetes, high TG, LDL-C level and C carriers of CD36 rs1049673 significantly affected risk for premature coronary heart disease PMID: 25299084
  81. transport of fat into the liver could be due to FAT/CD36 which is influenced by cytokines produced after irradiation PMID: 25197426
  82. Data suggest that CD36 (fatty acid translocase) in ventromedial hypothalamus plays role in neuronal sensing of free fatty acids and appetite regulation. [REVIEW] PMID: 25200296
  83. The frequency of CD36 deficiency in the Chinese population is slightly lower than that in other Asian countries. DNA sequencing analysis revealed 9 different mutations (6 new). The most frequent mutations were 329-330delAC and 1228-1239delATTGTGCCTATT. PMID: 25330908
  84. High affinity FA binding to CD36 and the effects of each FA on oxLDL uptake have important implications for protein conformation, binding of other ligands, functional properties of CD36 PMID: 25555908
  85. Cerebral malaria isolates bind significantly more to CD36 than to ICAM-1, which was correlated with high transcription level of group B var genes, supporting their implication in malaria pathogenesis. PMID: 25156105
  86. Data suggest CD36 binding site for long-chain free fatty acid (LC-FFA) is important in biological transport of LC-FFA from chylomicrons to VLDL; CD36 and LC-FFA participate in signal transduction to coordinate utilization of dietary fats. [REVIEW] PMID: 24850384
  87. This study unveils the presence of SR-A1, CD36, and LOX-1 in aortic valves and suggests potential mechanisms by which they may contribute to the pathological angiogenesis, inflammation, calcification, and lipid accumulation in AVS. PMID: 24929820
  88. Rheumatoid arthritis patients with subclinical atherosclerosis showed low membrane expression of CD36 in peripheral blood mononuclear cells and increased serum proinflammatory cytokines. PMID: 25006585
  89. These findings suggest that oxidized HDL enhances the pro-inflammatory properties and impairs the function of HK-2 cells, mainly through the scavenger receptor, CD36, as well as through the Src, MAPK and NF-kappaB pathways. PMID: 24919723
  90. CD36 expression is correlated with glioblastoma patient survival. PMID: 24737733
  91. Circulating CD36 and oxLDL levels are associated with cardiovascular risk factors in young subjects and may be potential early markers for cardiovascular disease. PMID: 24766787
  92. Enhanced CD36-mediated hepatic fat uptake may contribute to an accelerated progression of nonalcoholic fatty liver disease in mice and humans PMID: 24751397
  93. Plasma lipids, atherogenic risk factors and leukocyte functionality are important for the atherogenic process. PMID: 24679691
  94. CD36, HBA, NOS3 and VCAM1 variants are associated with chronic haemolysis level in sickle cell anaemia PMID: 24168396
  95. Receptor-mediated endocytosis of albumin by podocytes is regulated by the fatty acid moiety, although, some of the detrimental effects are induced independently of it. CD36 does not play a direct role in the uptake of albumin. PMID: 24815572
  96. Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development. PMID: 24060386
  97. oxLDL-induced NLRP3 inflammasome activation mainly depends on CD36 involved in the progression of atherosclerosis by promoting oxLDL-mediated inflammation and foam cell formation. PMID: 24121974
  98. Increased serum sCD36 is an independent factor associated with advanced steatosis in non-alcoholic fatty liver disease. PMID: 24134687
  99. High CD36 variant is associated with African Americans leading to cardiovascular disease susceptibility. PMID: 24643644
  100. CD36 mediated hematoma absorption after ICH, and TLR4 signaling inhibited CD36 expression to slow hematoma absorption. PMID: 24808360

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Involvement in disease Platelet glycoprotein IV deficiency (PG4D); Coronary heart disease 7 (CHDS7)
Subcellular Location Cell membrane, Multi-pass membrane protein, Membrane raft, Golgi apparatus, Apical cell membrane
Protein Families CD36 family
Database Links

HGNC: 1663

OMIM: 173510

KEGG: hsa:948

STRING: 9606.ENSP00000308165

UniGene: Hs.120949

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