CD3E Antibody

Datasheet
Code CSB-PA949010
Product Type Polyclonal Antibody
Size US$297
Uniprot No. P07766
Image
  • Western blot analysis of extract from Molt4 and JK cells using CD3E Antibody
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Peptide sequence around aa.197~201( D-L-Y-S-G) derived from Human CD3E.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Specificity The antibody detects endogenous level of total CD3E protein.
Tested Applications ELISA,WB;WB:1:500-1:1000
Relevance The CD3 complex mediates signal transduction.
Form Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality Polyclonal
Alias T3E; TCRE; FLJ18683
Immunogen Species Homo sapiens (Human)
Target Names CD3E
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways
Involvement in disease Immunodeficiency 18 (IMD18)
Subcellular Location Cell membrane, Single-pass type I membrane protein
Database Links

HGNC: 1674

OMIM: 186830

KEGG: hsa:916

STRING: 9606.ENSP00000354566

UniGene: Hs.3003

Pathway Hematopoietic cell lineage
T cell receptor signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation

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