CD3E Antibody, HRP conjugated

Datasheet
Code CSB-PA004931HB01HU
Size US$299
Uniprot No. P07766
Protocols ELISA Protocol
Immunogen Recombinant Human T-cell surface glycoprotein CD3 epsilon chain protein (23-126AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation. Required for normal immune responses (PubMed:15546002, PubMed:8490660).
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e), CD3E, T3E
Immunogen Species Homo sapiens (Human)
Research Area Immunology
Target Names CD3E
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways
Involvement in disease Immunodeficiency 18 (IMD18)
Subcellular Location Cell membrane, Single-pass type I membrane protein
Database Links

HGNC: 1674

OMIM: 186830

KEGG: hsa:916

STRING: 9606.ENSP00000354566

UniGene: Hs.3003

Pathway Hematopoietic cell lineage
T cell receptor signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation

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