CD53 Antibody

Code CSB-PA006200
Size US$167
Image
  • Western Blot analysis of KB cells using CD53 Polyclonal Antibody
  • Western Blot analysis of KB cells using CD53 Polyclonal Antibody
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Product Details

Uniprot No. P19397
Target Names CD53
Alternative Names AI323659 antibody; Antigen MOX44 identified by monoclonal antibody MRC-OX44 antibody; CD 53 antibody; CD53 antibody; CD53 antigen antibody; CD53 antigen; isoform CRA_b antibody; CD53 glycoprotein antibody; Cd53 molecule antibody; CD53 tetraspan antigen antibody; CD53_HUMAN antibody; Cell surface glycoprotein CD53 antibody; Leukocyte antigen MRC OX-44 antibody; Leukocyte surface antigen CD53 antibody; MOX 44 antibody; MOX44 antibody; OTTHUMP00000059505 antibody; Ox-44 antibody; OX44 antibody; RATOX44 antibody; Tetraspanin 25 antibody; Tetraspanin-25 antibody; Tetraspanin25 antibody; Transmembrane glycoprotein antibody; TSPAN 25 antibody; Tspan-25 antibody; TSPAN25 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the Internal region of Human CD53.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:10000
Protocols Western Blotting(WB) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).
Gene References into Functions
  1. In this study, significant and lineage-dependent association of CD53 locus with Tuberculosis (TB) onset was identified from the pathogen lineage-based genome-wide association study (GWAS). PMID: 28878339
  2. CD53 is associated with population asthma risk via the functional promoter polymorphism -1560 C>T. PMID: 23313165
  3. SNP rs6679497 in gene CD53 showed significant association with TNFalpha levels (P=0.001); no association of this SNP was observed with osteoarthritis PMID: 20407468
  4. Ligation of CD53 triggers a survival response and reduces the number of cells that enter apoptosis. The CD53 antigen interactions might contribute to cell survival in poorly vascularized regions of the tumor mass. PMID: 12606948
  5. Analysis of lymphocyte subsets showed that the total number of CD3+, CD4+, CD8+ and CD56+ lymphocytes increased after the intensive protocol before falling below pre-exercise values at 1 h post-exercise. PMID: 16506060
  6. The paradox is that lymphocytes from RA patients are believed to resist apoptosis, and we suggest that the elevated expression of CD53, which results from the increased oxidative stress, may protect against apoptosis. PMID: 17210617

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Subcellular Location Cell membrane, Cell junction, Membrane, Multi-pass membrane protein
Protein Families Tetraspanin (TM4SF) family
Tissue Specificity B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.
Database Links

HGNC: 1686

OMIM: 151525

KEGG: hsa:963

STRING: 9606.ENSP00000271324

UniGene: Hs.443057

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