CDC42EP2 Antibody

Code CSB-PA546490
Size US$297
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  • Western blot analysis of extracts from K562 cells, using BORG1 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CDC42EP2 Polyclonal antibody
Uniprot No.
Target Names
CDC42EP2
Alternative Names
Binder of Rho GTPases 1 antibody; BORG1 antibody; BORG1_HUMAN antibody; CDC42 effector protein (Rho GTPase binding) 2 antibody; Cdc42 effector protein 2 antibody; Cdc42ep2 antibody; CEP2 antibody; CRIB-containing BOGR1 protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human BORG1.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.
Gene References into Functions
  1. Studies indicate some of the functional and mechanistic roles of the binder of Rho GTPases Borg1-5 proteins (Cdc42EP1-5), including cytoskeletal remodelling and signalling. PMID: 27913681
  2. CDC42EP2 is upregulated in human PDLCs subjected to tensile stress related to mechano-induced cell cycle arrest. PMID: 20934684
  3. activations of Rac1 and Cdc42 are involved in the hypoxia-induced production of angiogenesis-promoting factors and tumor suppressors, and suggest that the Rho family GTPases Rac1 and Cdc42 may contribute to the hypoxia-mediated angiogenesis. PMID: 16395716
Subcellular Location
Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.
Protein Families
BORG/CEP family
Tissue Specificity
Highly expressed in the heart. Weakly expressed in the pancreas and liver.
Database Links

HGNC: 16263

OMIM: 606132

KEGG: hsa:10435

STRING: 9606.ENSP00000279249

UniGene: Hs.343380

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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