CDON Antibody

Datasheet

Code	CSB-PA679696LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, A549 whole cell lysate All lanes: CDON antibody at 3.4μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 140, 137 kDa Observed band size: 140 kDa Immunofluorescent analysis of MCF-7 cells using CSB-PA679696LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CDON Polyclonal antibody

Uniprot No.

Q4KMG0

Target Names

CDON

Alternative Names

CDO antibody; Cdon antibody; CDON_HUMAN antibody; Cell adhesion molecule-related/down-regulated by oncogenes antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Cell adhesion molecule-related/down-regulated by oncogenes protein (1095-1211AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CDON Antibody (Product code: CSB-PA679696LA01HU) is Non-conjugated. For CDON Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA679696LB01HU	CDON Antibody, HRP conjugated	ELISA
FITC	CSB-PA679696LC01HU	CDON Antibody, FITC conjugated
Biotin	CSB-PA679696LD01HU	CDON Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells.

Gene References into Functions

We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis PMID: 26529631
CDO is required for proliferation and survival of lung cancer cells via Hh signaling. PMID: 25369201
These data support the view that cell-adhesion molecule-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs. PMID: 25313246
Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer. PMID: 24740842
Mutations in the CDON cause holoprosencephaly. (Review) PMID: 22326621
We found that CDON is overexpressed in prostate cancer PMID: 21849809
CDON must associate with both ligand and other hedgehog-receptor components, particularly PTCH1, for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly. PMID: 21802063
Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner PMID: 20519495
CDO and BOC play a role in differentiation of cells in the skeletal muscle lineage PMID: 12720294
CDO and BOC forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact. PMID: 12634428
Targeted inactivation of Cdon in the mouse results in mild holoprosencephaly, suggesting a link to signaling pathways that control midline development such as the Sonic hedgehog pathway. PMID: 12620190

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Involvement in disease

Holoprosencephaly 11 (HPE11)

Subcellular Location

Cell membrane; Single-pass membrane protein.

Database Links

HGNC: 17104

OMIM: 608707

KEGG: hsa:50937

STRING: 9606.ENSP00000263577

UniGene: Hs.38034

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Related pathways

Hedgehog signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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