CDON Antibody

1. We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis PMID: 26529631
2. CDO is required for proliferation and survival of lung cancer cells via Hh signaling. PMID: 25369201
3. These data support the view that cell-adhesion molecule-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs. PMID: 25313246
4. Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer. PMID: 24740842
5. Mutations in the CDON cause holoprosencephaly. (Review) PMID: 22326621
6. We found that CDON is overexpressed in prostate cancer PMID: 21849809
7. CDON must associate with both ligand and other hedgehog-receptor components, particularly PTCH1, for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly. PMID: 21802063
8. Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner PMID: 20519495
9. CDO and BOC play a role in differentiation of cells in the skeletal muscle lineage PMID: 12720294
10. CDO and BOC forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact. PMID: 12634428
11. Targeted inactivation of Cdon in the mouse results in mild holoprosencephaly, suggesting a link to signaling pathways that control midline development such as the Sonic hedgehog pathway. PMID: 12620190

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HGNC: 17104

OMIM: 608707

KEGG: hsa:50937

STRING: 9606.ENSP00000263577

UniGene: Hs.38034