CENPA Antibody

Datasheet
Code CSB-PA097091
Product Type Polyclonal Antibody
Size US$297
Uniprot No. P49450
Image
  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using CENPA antibody.
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Synthesized peptide derived from internal of Human CENPA.
Raised in Rabbit
Species Reactivity Human
Specificity The antibody detects endogenous levels of total CENPA protein.
Tested Applications ELISA,IHC;IHC:1:50-1:100
Relevance Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).

Sullivan K.F., J. Cell Biol. 127:581-592(1994).
Hillier L.W., Nature 434:724-731(2005).
Shelby R.D., J. Cell Biol. 136:501-513(1997).
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality Polyclonal
Alias CENA; CENP-A; Centromere autoantigen A; Centromere protein A;
Immunogen Species Homo sapiens (Human)
Target Names CENPA
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes
Subcellular Location Nucleus, Chromosome, centromere, kinetochore, Chromosome, centromere
Protein Families Histone H3 family
Database Links

HGNC: 1851

OMIM: 117139

KEGG: hsa:1058

STRING: 9606.ENSP00000336868

UniGene: Hs.1594

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