CERS3 Antibody

Datasheet

Code	CSB-PA811597LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Mouse heart tissue All lanes: CERS3 antibody at 3.6μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 47 kDa Observed band size: 47 kDa
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Product Details
Citations
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CERS3 Polyclonal antibody

Uniprot No.

Q8IU89

Target Names

CERS3

Alternative Names

CERS3; LASS3; Ceramide synthase 3; CerS3; Dihydroceramide synthase 3; LAG1 longevity assurance homolog 3; Sphingosine N-acyltransferase CERS3; Ultra-long-chain ceramide synthase CERS3; Very-long-chain ceramide synthase CERS3

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Ceramide synthase 3 protein (59-134AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CERS3 Antibody (Product code: CSB-PA811597LA01HU) is Non-conjugated. For CERS3 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA811597LB01HU	CERS3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA811597LC01HU	CERS3 Antibody, FITC conjugated
Biotin	CSB-PA811597LD01HU	CERS3 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Electrolytic-reduction ion water induces ceramide synthesis in human skin keratinocytes H Yamamoto,Drug discoveries & therapeutics,2021

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 1 reviews

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Applications : Western blot assays

Sample type: Cells

Review: The protein levels of CerS3, ELOVL4, and β-actin were determined using lysates prepared from NHEK cells treated with 0.5%, 1%, or 5% ERI added to the cell culture medium for 72 h. The expression of CerS3 and ELOVL4 proteins was detected by western blotting analysis.

By Anonymous

Target Background

Function

Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation.

Gene References into Functions

Novel mutations in CERS3 co-segregated with the ichthyosis phenotype in six Iranian families. PMID: 28875980
testis-specific SLs, which we also link to CerS3 in human testis, are quintessential for male fertility. PMID: 26045466
Our findings demonstrate that synthesis of very long chain ceramides by CerS3 is a crucial early step for the skin barrier formation and link disorders presenting with congenital ichthyosis to defects in sphingolipid metabolism and lipid architecture. PMID: 23549421
these data present a novel pathway involved in ARCI development and, moreover, provide the first evidence that CERS3 plays an essential role in human sphingolipid metabolism for the maintenance of epidermal lipid homeostasis. PMID: 23754960

Involvement in disease

Ichthyosis, congenital, autosomal recessive 9 (ARCI9)

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue Specificity

Expressed in the epidermis, where it localizes at the interface between the stratum granulosum and the stratum corneum (at protein level).

Database Links

HGNC: 23752

OMIM: 615023

KEGG: hsa:204219

STRING: 9606.ENSP00000284382

UniGene: Hs.662371

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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