CLDN10 Antibody

1. The CLDN10 polymorphism of rs1325774 was significantly associated with an increased risk of breast cancer. After adjusting for age, the association remained statically significant. Furthermore, harbouring G allele in rs1325774 position was significantly associated with increased risk of breast cancer. However, no significant association among rs7333503, rs3751334, and breast cancer. PMID: 30544377
2. These renal-derived features recapitulate several phenotypic aspects detected in mice with kidney specific loss of both claudin-10 isoforms. Our study adds to the spectrum of phenotypes caused by tight junction proteins and demonstrates a pivotal role for claudin-10b in maintaining paracellular Na+ permeability for sweat production and kidney function. PMID: 28686597
3. localization of Cldn3, Cldn7 and Cldn10 proteins in the different compartments of murine endometrium up to day 8.5 of pregnancy (dpc) as well as in human endometrium and first trimester decidua PMID: 26340953
4. Expression of CLDN1 and CLDN10 was lower in invasive lepidic predominant adenocarcinoma than in lung adenocarcioma in situ. Overexpression of CLDN1 and CLDN10 indicates a favorable prognosis in some patients with lung adenocarcinoma. PMID: 23591077
5. Claudin 10 expression was down-regulated in gastric cancer. PMID: 24325792
6. In claudin-10b, the F66L mutant reduced cation selectivity, and the F66A mutant lost pore conductance PMID: 23760508
7. Claudin 10/18 are most commonly expressed in lung adenocarcinomas. Female patients and non-smokers express these claudins more commonly suggesting that they may play a part in the carcinogenesis of tobacco unrelated carcinoma. PMID: 22076167
8. Claudin 10 protein is highly expressed in hepatocellular carcinoma (HCC) tissue and is closely related to angiogenesis. It could be a useful marker to predict poor prognosis of HCC patients after hepatectomy. PMID: 21647678
9. CLDN10 is a novel biomarker for detecting ovarian cancer in the chicken, a suitable animal model for investigating the effect and function of CLDN in human ovarian cancer. PMID: 21370593
10. High Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma PMID: 15701840
11. These findings showed that CLDN-10 is functionally involved in hepatocellular carcinoma invasion and is a potential target for hepatocellular carcinoma therapy. PMID: 18025272
12. Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function. PMID: 19383724

Show More

Hide All

HGNC: 2033

OMIM: 617579

KEGG: hsa:9071

STRING: 9606.ENSP00000299339

UniGene: Hs.534377