PHLDA1 Antibody

1. suggest a unique regulatory feature of PHLDA1 to inhibit the ErbB receptor oligomerization process and thereby control the activity of receptor signaling network. PMID: 29233889
2. Data identified PHLDA1 as a novel p53 target with an ability to repress Akt. PHLDA1 has a so-called split PH domain divided into an N-terminal and a C-terminal portions and seems to be responsible for its localization to the plasma membrane and binding to phosphatidylinositol. In addition, PHLDA1 expression analysis suggests that PHLDA1 has a tumor suppressive function in breast and ovarian cancers. PMID: 30207029
3. Our study negatively correlates expression of PHLDA1 and Aurora A in IMR-32 cells and sheds new light on functions of PHLDA1 in the neuroblastoma tumor cells, suggesting its role as a pro-apoptotic protein PMID: 27278006
4. Suggest decreased expression of PHLDA1 may play an important role in tumor progression, and may become a new adjunct biomarker in the prognosis in gastric adenocarcinoma. PMID: 26191222
5. Data suggest that high PHLDA1 expression is controlled through an ER-NFkappaB-miR-181 regulatory axis and may contribute to a poor clinical outcome in patients with ER+ breast tumors by enhancing stem-like properties in these tumors. PMID: 24954507
6. PHLDA1 expression is a useful addition in differentiating trichoblastoma and basal cell carcinoma. PMID: 23719479
7. A role for PHLDA1 as an apoptosis suppressor in oral cancer cells. PMID: 24270013
8. Data show that downregulation of aurora A kinase by the therapeutic antibody is associated with decreased levels of MYCN protein in cytoplasm, and induced expression of PHLDA1 and P53 proteins. PMID: 23962557
9. The follicular stem cell marker PHLDA1 (TDAG51) indicates that most basaloid tumors in nevus sebaceus are basal cell carcinomas and not trichoblastomas. PMID: 23489134
10. PHLDA1 differentiates between desmoplastic trichoepithelioma and morpheaform basal cell carcinoma but shows variable staining in microcystic adnexal carcinoma. PMID: 23398472
11. the release of Ca(2+) from endoplasmic reticulum stores mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium via the induction of TDAG51 PMID: 22592641
12. crucial negative regulator and effector of Aurora A kinase in breast cancer PMID: 21807936
13. PHLDA1 expression marks the putative epithelial stem cells, downregulates ITGA2 and ITGA6, and contributes to intestinal tumorigenesis PMID: 21558389
14. The progressive loss of PHLDA1 expression in melanomas may play a role in deregulated cell growth and apoptosis resistance in these tumors. PMID: 12384558
15. expression of TDAG51 in human T-cells does not correlate with activation-induced cell death PMID: 15002043
16. TDAG51 plays an important role in the anti-apoptotic effects of IGF-I. PMID: 15037619
17. TDAG51 locus shows an operon-like organization of two head-to-head oriented transcripts that are inversely regulated in T lymphocytes by a CpG-rich bidirectional promoter. PMID: 15315823
18. Reduced PHLDA1 expression is important in breast cancer progression and could serve as useful prognostic marker of disease outcome. PMID: 17211533
19. TDAG51 in patients with intractable epilepsy was significantly higher when compared with levels in the controls. PMID: 17870236
20. The anti-estrogen ICI 182,780 (1 microM) inhibited PHLDA1 mRNA expression and completely abolished the effect of 10 nM 17beta-estradiol on PHLDA1 expression (P < 0.05), suggesting that PHLDA1 is regulated by estrogen via ER. PMID: 18641796

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HGNC: 8933

OMIM: 605335

KEGG: hsa:22822

STRING: 9606.ENSP00000266671

UniGene: Hs.602085