CLIP2 Antibody

Code CSB-PA871393LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: Rat brain tissue, Mouse brain tissue
    All lanes: CLIP2 antibody at 3.2μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 116, 112 kDa
    Observed band size: 116 kDa

  • Immunofluorescence staining of A549 cells with CSB-PA871393LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CLIP2 Polyclonal antibody
Uniprot No.
Target Names
CLIP2
Alternative Names
CAP GLY domain containing linker protein 2 antibody; CAP-Gly domain-containing linker protein 2 antibody; CLIP 115 antibody; CLIP antibody; CLIP-115 antibody; Clip2 antibody; CLIP2_HUMAN antibody; cytoplasmic linker 2 antibody; Cytoplasmic linker protein 115 antibody; Cytoplasmic linker protein 2 antibody; KIAA0291 antibody; MGC11333 antibody; restin antibody; Similar to RESTIN (CYTOPLASMIC LINKER PROTEIN 170 ALPHA 2) antibody; WBSCR3 antibody; WBSCR4 antibody; Williams Beuren syndrome chromosome region 3 antibody; Williams Beuren syndrome chromosome region 4 antibody; Williams-Beuren syndrome chromosomal region 3 protein antibody; Williams-Beuren syndrome chromosomal region 4 protein antibody; WSCR3 antibody; WSCR4 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Human CAP-Gly domain-containing linker protein 2 protein (101-217AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CLIP2 Antibody (Product code: CSB-PA871393LA01HU) is Non-conjugated. For CLIP2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA871393LB01HU CLIP2 Antibody, HRP conjugated ELISA
FITC CSB-PA871393LC01HU CLIP2 Antibody, FITC conjugated
Biotin CSB-PA871393LD01HU CLIP2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations.
Gene References into Functions
  1. Cross checking with epidemiological estimates and model validation suggests that CLIP2 is a marker of high precision. CLIP2 leaves an imprint in the epidemiological incidence data which is typical for a driver gene. PMID: 27729373
  2. CLIP2 protein expression is elevated in papillary thyroid carcinomas from patients exposed to radioiodine fallout compared with a nonexposed control group. PMID: 25284583
  3. A clear radiation dose-response relationship for the CLIP2 marker expression in post-Chernobyl papillary thyroid carcinomas PMID: 25957251
  4. CLIP2 haploinsufficiency by itself does not lead to the physical or cognitive characteristics of the Williams-Beuren syndrome; GTF2IRD1 and GTF2I are the main genes causing the cognitive defects PMID: 22608712
  5. Data show that gene CLIP2 was specifically overexpressed in the exposed cases. PMID: 21606360

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Involvement in disease
CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region (PubMed:9799601). WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. However, it has been demonstrated that haploinsufficiency of this gene alone is not sufficient to cause any of the cognitive or facial features of WBS (PubMed:22608712).
Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton.
Database Links

HGNC: 2586

OMIM: 603432

KEGG: hsa:7461

STRING: 9606.ENSP00000223398

UniGene: Hs.647018

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