COLEC10 Antibody

Datasheet

Code	CSB-PA896556LA01HU
Size	US$166
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Image	IHC image of CSB-PA896556LA01HU diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA896556LA01HU diluted at 1:300 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
Citations
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) COLEC10 Polyclonal antibody

Uniprot No.

Q9Y6Z7

Target Names

COLEC10

Alternative Names

CL-34 antibody; CL-L1 antibody; CLL1 antibody; COL10_HUMAN antibody; Colec10 antibody; Collectin liver 1 antibody; Collectin liver protein 1 antibody; Collectin sub family member 10 (C-type lectin) antibody; Collectin sub family member 10 antibody; Collectin subfamily member 10 antibody; Collectin-10 antibody; Collectin-34 antibody; MGC118794 antibody; MGC118795 antibody; OTTHUMP00000228058 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Collectin-10 protein (28-277AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The COLEC10 Antibody (Product code: CSB-PA896556LA01HU) is Non-conjugated. For COLEC10 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA896556LB01HU	COLEC10 Antibody, HRP conjugated	ELISA
FITC	CSB-PA896556LC01HU	COLEC10 Antibody, FITC conjugated
Biotin	CSB-PA896556LD01HU	COLEC10 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

The C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis M Zhang,Cell death & disease,2023

Customer Reviews and Q&A

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Target Background

Function

Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Acts as a chemoattractant, probably involved in the regulation of cell migration.

Gene References into Functions

High CLL1 expression is associated with cardiovascular disease. PMID: 27341702
Exome sequencing reveals mutations in collectin sub-family member 10 (C-type lectin) protein (COLEC10) as a cause of 3MC syndrome with main features include facial dysmorphism, craniosynostosis and cleft lip/palate. PMID: 28301481
high serum CL-L1 concentration in critically ill children upon PICU admission is associated with an increased risk of infection and prolonged need of intensive care, and counteracts the protective effect of having a high MASP-3 concentration PMID: 27057739
Data indicate differences in the plasma concentrations of collectin liver 1 and collectin kidney 1, M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls. PMID: 26154564
Carriers of COLEC10 Arg125Trp had increased CL-L1 serum levels. PMID: 25710878
Most plasma CL-K1 was found in complex with CL-L1 in a ratio suggesting a heteromeric subunit of 1 CL-L1 & 2 CL-K1 polypeptides. PMID: 24174618

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Involvement in disease

3MC syndrome 3 (3MC3)

Subcellular Location

Secreted. Golgi apparatus. Cytoplasm.

Protein Families

COLEC10/COLEC11 family

Tissue Specificity

Highly expressed in liver, placenta and adrenal gland. Moderately expressed in small intestine, lung, stomach and prostate. Weakly expressed in trachea and spleen.

Database Links

HGNC: 2220

OMIM: 248340

KEGG: hsa:10584

STRING: 9606.ENSP00000332723

UniGene: Hs.176615

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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