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COMMD5 Antibody

Datasheet
Code CSB-PA005773GA01HU
Size $600
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Product Details

Uniprot No.
Q9GZQ3
Target Names
COMMD5
Alternative Names
COMMD5 antibody; HT002COMM domain-containing protein 5 antibody; Hypertension-related calcium-regulated gene protein antibody; HCaRG antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human COMMD5
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
Gene References into Functions
  1. the hypertension-related, calcium-regulated gene (HCaRG/COMMD5) is involved in renal repair. PMID: 24515317
  2. HCaRG accelerates repair of renal proximal tubules by modulating cell proliferation of resident tubular epithelial cells and by facilitating redifferentiation. PMID: 21921141
  3. The gene for human HCaRG is located on chromosome 8q24.3. PMID: 11871861
  4. The up-regulation of HCaRG may be one of the mechanisms underlying the chemopreventive effect of rosiglitazone in gastric cancer. PMID: 18949406
Subcellular Location
Cytoplasm. Nucleus.
Tissue Specificity
Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver.
Database Links

HGNC: 17902

OMIM: 608216

KEGG: hsa:28991

STRING: 9606.ENSP00000304544

UniGene: Hs.493218

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