INTS11 Antibody

Code CSB-PA722574ESR1HU
Size US$166
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  • Western blot
    All lanes: INTS11 antibody at 2µg/ml
    Lane 1: Colo320 whole cell lysate
    Lane 2: Hela whole cell lysate
    Lane 3: MCF-7 whole cell lysate
    Secondary
    Goat polyclonal to Rabbit IgG at 1/10000 dilution
    Predicted band size: 68, 57, 66, 65, 69 kDa
    Observed band size: 68 kDa

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA722574ESR1HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) INTS11 Polyclonal antibody
Uniprot No.
Target Names
INTS11
Alternative Names
2410006F12Rik antibody; AU044035 antibody; Cleavage and polyadenylation specific factor 3 like antibody; Cleavage and polyadenylation-specific factor 3-like protein antibody; CPSF3 like protein antibody; CPSF3-like protein antibody; CPSF3L antibody; CPSF73L antibody; FLJ13294 antibody; FLJ20542 antibody; Human integrator complex subunit 11 antibody; INT 11 antibody; Int11 antibody; INT11_HUMAN antibody; Integrator complex subunit 11 antibody; INTS 11 antibody; INTS11 antibody; MGC124975 antibody; OTTHUMP00000044092 antibody; Protein related to CPSF subunits of 68 kDa antibody; RC 68 antibody; RC 68, related antibody; RC-68 antibody; RC68 antibody; Related to CPSF subunits 68 kDa antibody; Related to CPSF subunits, 68 kDa protein antibody; RGD1306841 antibody; RP23 242K15.19 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Integrator complex subunit 11 protein (331-600AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Customer Reviews and Q&A

 Customer Reviews
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Applications : Quantitative mass spectrometry assays

Sample type: Human Cell

Review: Quantitative mass spectrometry assays showing co-enrichment of the potential interaction partners by INTS4/9/11.

By Anonymous

Target Background

Function
Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
Gene References into Functions
  1. Functional studies demonstrate that the IntS9-IntS11 interaction is crucial for the role of INT in snRNA 3'-end processing. PMID: 28396433
  2. The specific heterodimeric interaction between IntS9 and IntS11 is mediated by a discrete domain present at the extreme C terminus of IntS9 and within the C terminus of IntS11, adjacent to the predicted active site of this endonuclease. PMID: 22252320
Subcellular Location
Nucleus. Cytoplasm.
Protein Families
Metallo-beta-lactamase superfamily, RNA-metabolizing metallo-beta-lactamase-like family, INTS11 subfamily
Database Links

HGNC: 26052

OMIM: 611354

KEGG: hsa:54973

STRING: 9606.ENSP00000413493

UniGene: Hs.6449

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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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