INTS11 Antibody

Datasheet

Code	CSB-PA722574ESR2HU
Size	US$166
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Image	Western blot All lanes: CPSF3Lantibody at 4.2μg/ml Lane 1: Colo320 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: MCF-7 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 68, 57, 66, 65, 69 kDa Observed band size: 68 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA722574ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA722574ESR2HU at dilution of 1:100
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) INTS11 Polyclonal antibody

Uniprot No.

Q5TA45

Target Names

INTS11

Alternative Names

2410006F12Rik antibody; AU044035 antibody; Cleavage and polyadenylation specific factor 3 like antibody; Cleavage and polyadenylation-specific factor 3-like protein antibody; CPSF3 like protein antibody; CPSF3-like protein antibody; CPSF3L antibody; CPSF73L antibody; FLJ13294 antibody; FLJ20542 antibody; Human integrator complex subunit 11 antibody; INT 11 antibody; Int11 antibody; INT11_HUMAN antibody; Integrator complex subunit 11 antibody; INTS 11 antibody; INTS11 antibody; MGC124975 antibody; OTTHUMP00000044092 antibody; Protein related to CPSF subunits of 68 kDa antibody; RC 68 antibody; RC 68, related antibody; RC-68 antibody; RC68 antibody; Related to CPSF subunits 68 kDa antibody; Related to CPSF subunits, 68 kDa protein antibody; RGD1306841 antibody; RP23 242K15.19 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Integrator complex subunit 11 protein (331-600AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.

Gene References into Functions

Functional studies demonstrate that the IntS9-IntS11 interaction is crucial for the role of INT in snRNA 3'-end processing. PMID: 28396433
The specific heterodimeric interaction between IntS9 and IntS11 is mediated by a discrete domain present at the extreme C terminus of IntS9 and within the C terminus of IntS11, adjacent to the predicted active site of this endonuclease. PMID: 22252320

Subcellular Location

Nucleus. Cytoplasm.

Protein Families

Metallo-beta-lactamase superfamily, RNA-metabolizing metallo-beta-lactamase-like family, INTS11 subfamily

Database Links

HGNC: 26052

OMIM: 611354

KEGG: hsa:54973

STRING: 9606.ENSP00000413493

UniGene: Hs.6449

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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