CPT1C Antibody

1. Depletion of PPARalpha resulted in low CPT1C expression. PMID: 28334197
2. CPT1C binds malonyl-CoA and long-chain acyl-CoA suggest that it is a sensor of lipid metabolism in neurons, where it appears to impact ceramide and triacylglycerol metabolism. [review] PMID: 26708865
3. CPT1c is found in brain regions that are related to food intake and neuropsychiatric disease. CPT1c affects ceramide levels, endocannabionoids, and oxidative processes and may play an important role in various brain functions such as learning. PMID: 26041663
4. CPT1C mutation associated with novel form of pure autosomal dominant hereditary spastic paraplegia. PMID: 25751282
5. High grade glioblastoma is associated with increased level of ZFP57, a protein involved in gene imprinting, and aberrant expression of CPT1A and CPT1C. PMID: 24618825
6. Data suggest that an involvement of CPT1C in cellular energy-sensing pathways and provide evidence for a role of CPT1C in hypothalamic regulation of energy homeostasis. PMID: 21961029
7. cells can use a novel mechanism involving CPT1C and fatty acid metabolism to protect against metabolic stress PMID: 21576264
8. CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity PMID: 18192268
9. Accumulation of 3-hydroxylated intermediates of long-chain fatty acids may contribute to the pathogenesis of retinopathy in MTP deficiencies. PMID: 18385088

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HGNC: 18540

OMIM: 608846

KEGG: hsa:126129

STRING: 9606.ENSP00000319343

UniGene: Hs.112195