CRABP2 Antibody

1. Semiquantitative and quantitative analyses of the markers RARA and CRABP2 indicate their potential as biomarkers for tumor progression and their participation in nephroblastoma tumorigenesis PMID: 29378601
2. These data suggest a retinoic acid-independent, non-tumor suppressor role of CRABP2 for the survival of Malignant peripheral nerve sheath tumor (MPNST) cells in vitro. Targeting CRABP2 overexpression may represent a unique approach for the treatment of human MPNST. PMID: 28502478
3. A high expression ratio between FABP5 and CRABPII may be related to CP tumor recurrence and ATRA could be a potential therapeutic agent for CP chemotherapy. PMID: 27418530
4. reducing CRABP2 levels may enhance the therapeutic index of Retinoic acid in glioblastoma multiforme patients PMID: 26893190
5. in esophageal squamous carcinogenesis by significantly inhibiting cell growth, inducing cell apoptosis and blocking cell metastasis both in vitro and in vivo PMID: 26839961
6. The anticarcinogenic activities of CRABP2 are mediated by both HuR and RAR. PMID: 25320093
7. CBX3 and CRABP2 expression was markedly increased in lung cancer tissues PMID: 24751108
8. Reengineering of cellular retinoic acid binding protein II (CRABPII) to be capable of binding retinal as a protonated Schiff base is described PMID: 24059243
9. CRABP2 controls mRNA stabilization by HuR. PMID: 24687854
10. overexpression of CRABP-II is a late event of pancreatic carcinogenesis, and it could be used as a diagnostic marker PMID: 24709110
11. all three proteins (RDH10, RALDH2, and CRABP2) appeared to be required for ATRA production induced by activation of PPARgamma PMID: 23833249
12. E-FABP showed high exp ression in NSCLC, and the increased E-FABP expression may involved in the occurrence and development of NSCLC PMID: 23327868
13. Hypermethylation in the CpG island of the CRABP2 gene is associated with astrocytic gliomas. PMID: 22275178
14. Aberrant methylation in CRABP-II reduces the expression of CRABP-II that in turn confers retinoic acid resistance in medulloblastoma cells. PMID: 22153617
15. Low CRABP2 is associated with pancreatic ductal adenocarcinoma. PMID: 22010213
16. Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation PMID: 21998312
17. Trophoblast spheroids cocultured with endometrial cells overexpressing CRABP2 are defective in expansion and exhibit apoptosis, suggesting that CRABP2 is involved in abnormal endometrium-trophoblast interaction, leading to implantation failure. PMID: 21605859
18. Data show that NIPER-4 induces cIAP1-mediated ubiquitylation of CRABP-II, resulting in the proteasomal degradation. PMID: 21414315
19. Individual variation in ALDH1A2/CRABP2 genes may account for subtle variations in retinoic acid-dependent human embryogenesis. PMID: 20308937
20. Data sghow a higher frequency of CRABP2 and MX1 hypermethylation in primary HNSCC when compared with lymphocytes from healthy individuals. PMID: 20019841
21. Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest. PMID: 11909957
22. Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of this protein PMID: 12482873
23. In this study, we excluded mutations within the complete coding region and the promoter of LMNA and the CRABP II gene in HIV-1 infected patients with lipodystrophy PMID: 12844477
24. CRABP-II has a role in wound re-epithelialisation by dermal fibroblasts PMID: 14766225
25. Phosphorylation/dephosphorylation of retinoic x receptor alpha via protein kinase C may be involved in the regulation of CRABP-II gene expression. PMID: 15225641
26. Data suggest that the ligand-controlled nuclear localization signal of CRABP-II may represent a general mechanism for posttranslational regulation of the subcellular distribution of a protein. PMID: 15866176
27. Transient transfection of either all-trans-retinoic acid (ATRA) receptor alpha or estrogen receptor alpha expression vectors increased CRABPII expression in MDA-MB-231 cells PMID: 15870697
28. CRABP-II overexpression in CAKI-2 RCC cells did not significantly influence RA associated antiproliferative actions. PMID: 16215318
29. MycN binds to the promoter of CRABP-II and induces CRABP-II transcription directly in neuroblastoma. PMID: 16912187
30. Results describe the structure of apo-wild type (WT) CRABPII at 1.35 A and show that apo- and holo-CRABPII share very similar structures. PMID: 16979656
31. AP2 factors regulate CRABPII expression in human mammary epithelial cells and breast cancer cells PMID: 17187826
32. results show that the CRABP2 gene is associated with increased plasma LDL-C concentrations. Carriers of the C allele had significantly higher LDL-C in healthy males, HIV-infected patients, and patients with familial hypercholesterolemia PMID: 17484622
33. Retinoic acid and retinol regulate expression of cellular retinol binding protein 1 and cellular RA binding protein 2 in fibroid and myometrial cells. PMID: 18343808
34. MycN and DNA methylation are responsible for CRABP-II expression in pediatric tumors and demethylation of CRABP-II may be an early event in tumor development. PMID: 18955045
35. Derangement/lack of a critical factor necessary for RARalpha function induces epigenetic repression of a RA-regulated gene network downstream of RARalpha, with major pleiotropic biological outcomes. PMID: 19173001

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HGNC: 2339

OMIM: 180231

KEGG: hsa:1382

STRING: 9606.ENSP00000357204

UniGene: Hs.405662