CROT Antibody

Datasheet

Code	CSB-PA891723ESR1HU
Size	US$166
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Image	Western blot All lanes: CROT antibody at 3μg/ml Lane 1: Mouse kidney tissue Lane 2: A431 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 71, 11, 74 kDa Observed band size: 71 kDa Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA891723ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA891723ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CROT Polyclonal antibody

Uniprot No.

Q9UKG9

Target Names

CROT

Alternative Names

Carnitine O octanoyltransferase antibody; COT antibody; CROT antibody; OCTC_HUMAN antibody; Peroxisomal carnitine acyltransferase antibody; Peroxisomal carnitine O octanoyltransferase antibody; Peroxisomal carnitine O-octanoyltransferase antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Peroxisomal carnitine O-octanoyltransferase protein (1-87AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.

Gene References into Functions

These results suggest that CROT activity, by controlling the peroxisomal amount of medium chain acyls, may control the peroxisomal oxidative pathway. PMID: 21619872
Selected 'Tpl2/Cot-YL ribozyme' efficiently cleaves its target sequence in cis and in trans; furthermore, the ribozyme efficiently cleaves a longer target sequence of 54 nucleotides in trans, as well as the full-length mRNA. PMID: 19054068
Human CPT1A, CPT1B, CPT2, CROT and CRAT are known to encode active carnitine acyltransferases. Earlier pfam annotations refer to the non-existing compound CARNITATE. In 2000 this has been changed to CARNITINE. PMID: 11001805
CROT encodes carnitine octanoyltransferase, an enzyme known from rat studies to act on products of peroxisomal fatty acid oxidation. Medium-chain acylcarnitines are thought to be transported from peroxisomes to mitochondria. PMID: 11001805

Subcellular Location

Peroxisome.

Protein Families

Carnitine/choline acetyltransferase family

Database Links

HGNC: 2366

OMIM: 606090

KEGG: hsa:54677

STRING: 9606.ENSP00000413575

UniGene: Hs.125039

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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