CRTC2 Antibody

1. Study suggests that Creb/Crtc2 negatively regulates the Sirt1/Pparalpha/Fgf21 axis via the induction of miR-34a under diet-induced obesity and insulin-resistant conditions. PMID: 29192248
2. Thyroid stimulating hormone activates CRTC2 via the TSHR/cAMP/PKA pathway. PMID: 28212844
3. CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in transplant recipients after solid organ transplantation. PMID: 26644205
4. CRTC2 strongly enhances GR-induced transcriptional activity of glucocorticoid-responsive genes. PMID: 26652733
5. Our results establish a role for CRTC2 as a lymphoma tumor suppressor gene PMID: 26004186
6. the high expression of CRTC2 and PROM1 may play an important role in the occurrence and hereditary, and also advance the potential pathways that integrate genetic variants in the development of NSCLC. PMID: 25256670
7. The data from the current study demonstrated novel PROM1 and CRTC2 mutations, which could promote lung cancer development. PMID: 24484648
8. These results clearly indicate that non-phosphorylated CRTC2 strongly enhances hepatitis b virus biosynthesis through inducing PGC1alpha expression. PMID: 24529027
9. Phosphorylation of CRTC2 at its AMPK target site, Ser 171, dictated its subcellular localization, and the activation of aromatase PII in preadipocytes. PMID: 23584792
10. CRTC2 enhances CREB phosphorylation through an association with the protein arginine methyltransferase 5 (PRMT5). PMID: 23671120
11. Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2 PMID: 23213254
12. The lipogenic effects of GIP in the presence of insulin are therefore at least partially mediated by upregulation of adipocyte LPL gene transcription through a pathway involving PI3-K/PKB/AMPK-dependent CREB/TORC2 activation. PMID: 20693566
13. the association of Pin1 with CRTC2 to decrease the nuclear CBP.CRTC.CREB complex. PMID: 20675384
14. Tax binds the cyclin D1 promoter-proximal cyclic AMP response element (CRE) in the presence of phosphorylated CREB (pCREB) in vitro, and together the Tax-pCREB complex recruits the cellular co-activator p300 to the promoter. PMID: 20101207
15. Thus, both TORC1/2 and p300 families of coactivators are essential for optimal activation of HTLV-1 transcription by Tax. PMID: 16809310
16. latent cytoplasmic coactivator TORC2 mediates target gene activation in response to cAMP signaling by associating with CBP/p300 and increasing its recruitment to a subset of CREB target genes PMID: 17476304
17. TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation. PMID: 17548807
18. genetic variants of LKB1-AMPK-TORC2 pathway components may exert a weak influence on the occurrence of type 2 diabetes in Japanese PMID: 17950019
19. identify Ser-275 of TORC2 as a 14-3-3 binding site that is phosphorylated under low glucose conditions and which becomes dephosphorylated by calcineurin in response to glucose influx PMID: 18626018
20. TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein. PMID: 19164291
21. The regulation of aromatase by CRTC2, in response to the altered hormonal milieu associated with menopause and obesity, provides a critical link between obesity and breast cancer. PMID: 19509226

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HGNC: 27301

OMIM: 608972

KEGG: hsa:200186

STRING: 9606.ENSP00000357622

UniGene: Hs.406392