CTBP2 Antibody

Code CSB-PA062537
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA062537(CTBP2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA062537(CTBP2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: PC3 cells, Primary antibody: CSB-PA062537(CTBP2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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Product Details

Uniprot No.
Target Names
CTBP2
Alternative Names
C terminal binding protein 2 antibody; C-terminal-binding protein 2 antibody; CtBP2 antibody; CTBP2_HUMAN antibody; ribeye antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Fusion protein of Human CTBP2
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
IHC 1:25-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation.; Isoform 2 probably acts as a scaffold for specialized synapses.
Gene References into Functions
  1. the present study indicated that CtBP2 reduced the susceptibility of ECA109 cells to cisplatin by regulating the expression of apoptosis-related proteins, suggesting that it may be a promising therapeutic target in esophageal squamous cell carcinoma in the future. PMID: 29658564
  2. Results indicated that CTBP2 was direct target of miR-338-5p in glioma cells. CTBP2 silencing can rescued the phenotype changes induced by miR-338-5p inhibitor on cell proliferation and invasion in glioma. PMID: 28826173
  3. this study shows that CtBP2 overexpression promotes tumor cell proliferation and invasion in gastric cancer and is associated with poor prognosis PMID: 28404932
  4. these findings provide insight into the role CtBP2 plays in promoting proliferation and migration in breast cancer by the inhibition of p16INK4A. PMID: 28412731
  5. CtBP2 ameliorated palmitic acid-induced insulin resistance via ROS-dependent JNK pathway. PMID: 28111233
  6. CtBP2 is a druggable transforming oncoprotein critical for the evolution of neoplasia driven by Apc mutation. PMID: 28414304
  7. CtBP2 may be a potential target to suppress tumorigenesis in neuroblastoma PMID: 28179207
  8. This Gene-based tests suggest evidence of association with related genes, ZEB2, RND3, MCTP1, CTBP2, and beta EEG PMID: 28040410
  9. Our results indicated that CCNH/CDK7-CtBP2 axis may augment ESCC cell migration, and targeting the interaction of both may provide a novel therapeutic target of esophageal squamous cell carcinoma . PMID: 25820824
  10. Releasing the key adipogenic regulator C/EBPalpha from CtBP2 binding. PMID: 25895816
  11. Enhanced CtBP2expression promoted HCC xenograft growth and induced EMT. PMID: 25686837
  12. results show how CtBP2 contributes to prostate cancer progression by modulating AR and oncogenic signaling PMID: 25228652
  13. High CTBP2 expression is associated with prostate cancer. PMID: 24332637
  14. Overexpression of CtBP2 is associated with breast carcinoma. PMID: 24522810
  15. CtBP2 might contribute to the progression of esophageal squamous cell carcinoma through a negative transcriptional regulation of p16(INK4A). PMID: 23255392
  16. CtBP2 is over-expressed in prostate cancer.CtBP2 promotes prostate cancer cell proliferation through c-Myc signaling. PMID: 24835310
  17. BRCA1 expression is epigenetically repressed in sporadic ovarian cancer cells by overexpression of C-terminal binding protein 2.CtBP2 is an ovarian cancer oncogene. PMID: 23730208
  18. CtBP2 directly targeted stem cell core genes resulting in increased cancer cell stemness and increasing metastatic and tumorigenic potential. PMID: 24012420
  19. E2F7 recruits the co-repressor C-terminal-binding protein (CtBP) and that CtBP2 is essential for E2F7 to repress E2F1 transcription. PMID: 23853115
  20. CTBP2 is a transcriptional cofactor for RXR-alpha/RAR-alpha. PMID: 23775127
  21. We propose that CtBP2 is an ovarian cancer oncogene that regulates gene expression program by modulating HDAC activity. PMID: 22945647
  22. these data demonstrate that CHIP regulates the steady-state level of CtBP2 as an E3 ubiquitin ligase and determines the expression levels of CtBP2 target genes. PMID: 23410750
  23. Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CDK7) stabilizes C-terminal binding protein 2 (CtBP2) and promotes cancer cell migration PMID: 23393140
  24. Doubly transgenic zebrafish exhibit a startle response and typical swimming behavior, indicating that there is no gross disruption of either hearing or vestibular function useful in the study of ribbon synapse development of the hair cell. PMID: 21334379
  25. This study demonstrates that ataxin-1 occupies the promoter region of E-cadherin in vivo and that ataxin-1 activates the promoter in a CtBP2-mediated transcriptional regulation manner. PMID: 21315774
  26. we demonstrate that it is the interaction of CtBPs with transcriptional regulators and/or chromatin-modifying enzymes in the cell nucleus, rather than their role in Golgi fission, which is critical for the maintenance of mitotic fidelity. PMID: 21057548
  27. CtBP2 proteins are ubiquitously expressed in all lines and tumour samples. PMID: 20964627
  28. CtBP2 selectively down-regulates Th2 cytokines, therefore it is a potential target for the treatment of allergic diseases. PMID: 20523059
  29. Data suggest that ARF antagonism of CtBP repression of Bik and other BH3-only genes may have a critical role in ARF-induced p53-independent apoptosis and tumor suppression. PMID: 19798104
  30. roles of acetylation in regulating subcellular localization and transcriptional activity of CtBP2. PMID: 16356938
  31. analysis of the CtBP2 corepressor complex induced by E1A and modulation of E1A transcriptional activity by CtBP2 PMID: 17023432
  32. E1A may gain access to cellular promoters through conservved sequence-dependent interaction with CtBP2. PMID: 17546044
  33. Study shows that transcription corepressor CtBP2 directly binds acinus, which is regulated by nerve growth factor (NGF), inhibiting its stimulatory effect on cyclin A1, but not cyclin A2, expression in leukemia. PMID: 19668232
  34. CtBP2 monomer interacts with a major CtBP-dependent repressor ZEB and HDAC and that the interaction of the two factors with the CtBP2 monomer was mutually exclusive. PMID: 19754958
  35. Genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 18264096

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Subcellular Location
Nucleus. Cell junction, synapse.
Protein Families
D-isomer specific 2-hydroxyacid dehydrogenase family
Tissue Specificity
Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.
Database Links

HGNC: 2495

OMIM: 602619

KEGG: hsa:1488

STRING: 9606.ENSP00000311825

UniGene: Hs.501345

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