CTSZ Antibody

Code CSB-PA006206LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA006206LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA006206LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CTSZ Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Carboxypeptidase LB antibody; Cathepsin B2 antibody; Cathepsin IV antibody; Cathepsin P antibody; Cathepsin X antibody; Cathepsin X precursor antibody; Cathepsin Y antibody; Cathepsin Z antibody; Cathepsin Z precursor antibody; Cathepsin Z1 antibody; CathepsinP antibody; CathepsinX antibody; CathepsinZ antibody; CATZ_HUMAN antibody; CTSX antibody; CTSZ antibody; Cysteine type carboxypeptidase antibody; FLJ17088 antibody; Lysosomal carboxypeptidase B antibody; Preprocathepsin P antibody; PreprocathepsinP antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Cathepsin Z protein (127-287AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The CTSZ Antibody (Product code: CSB-PA006206LA01HU) is Non-conjugated. For CTSZ Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA006206LB01HU CTSZ Antibody, HRP conjugated ELISA
FITC CSB-PA006206LC01HU CTSZ Antibody, FITC conjugated
Biotin CSB-PA006206LD01HU CTSZ Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides.
Gene References into Functions
  1. Down-regulation of RPLP0 resulted in G1 arrest of gastric cancer cells, whereas knockdown of Cathepsin X led to G1 arrest and apoptosis PMID: 25433997
  2. Cathepsin X (CTSX) is involved in early tumorigenesis and in the stabilization of tumor cell formation in colorectal cancer. PMID: 25442015
  3. The significant association of cathepsin X with survival in a group of patients who received no chemotherapy and the absence of this association in the group who received chemotherapy, suggest the possible predictive value for response to chemotherapy. PMID: 24725597
  4. Suggest CTSZ rs34069356 polymorphism is not associated with pulmonary tuberculosis in a sample Iranian population. PMID: 23827504
  5. We show that sequential cleavage of C-terminal amino acids from the beta(2) cytoplasmic tail of LFA-1, by CatX, enhances binding of the adaptor protein talin to LFA-1 and triggers formation of the latter's high-affinity form PMID: 21454358
  6. cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma PMID: 21966391
  7. cathepsin X deficiency leads to accelerated cellular senescence and consequently to diminished cellular proliferation and migration/invasion implying a potential role of cathepsin X in bypassing cellular senescence. PMID: 21616554
  8. Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility. PMID: 21368909
  9. associated with tuberculosis in a Ugandan household contact study PMID: 21354459
  10. Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin. PMID: 21310951
  11. These results show that cathepsin P, in contrast to other mammalian cathepsins, has a restricted catalytic specificity. PMID: 15680921
  12. the extracellular function of cathepsin X may include binding to integrins thereby modulating the attachment of migrating cells to ECM components [Cathepsin X] PMID: 17065156
  13. unlikely that CTSZ gene plays a major role in tuberculosis susceptibility in African populations PMID: 18420963

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Subcellular Location
Lysosome.
Protein Families
Peptidase C1 family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 2547

OMIM: 603169

KEGG: hsa:1522

STRING: 9606.ENSP00000217131

UniGene: Hs.252549

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