Cleaved-CTSZ (L62) Antibody

Code CSB-PA000038
Size US$100
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  • Western Blot analysis of COS7 cells using Cleaved-Cathepsin Z (L62) Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
CTSZ
Alternative Names
Carboxypeptidase LB antibody; Cathepsin B2 antibody; Cathepsin IV antibody; Cathepsin P antibody; Cathepsin X antibody; Cathepsin X precursor antibody; Cathepsin Y antibody; Cathepsin Z antibody; Cathepsin Z precursor antibody; Cathepsin Z1 antibody; CathepsinP antibody; CathepsinX antibody; CathepsinZ antibody; CATZ_HUMAN antibody; CTSX antibody; CTSZ antibody; Cysteine type carboxypeptidase antibody; FLJ17088 antibody; Lysosomal carboxypeptidase B antibody; Preprocathepsin P antibody; PreprocathepsinP antibody
Raised in
Rabbit
Species Reactivity
Human,Monkey
Immunogen
Synthesized peptide derived from the Internal region of Human Cathepsin Z.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity. Capable of producing kinin potentiating peptides.
Gene References into Functions
  1. Down-regulation of RPLP0 resulted in G1 arrest of gastric cancer cells, whereas knockdown of Cathepsin X led to G1 arrest and apoptosis PMID: 25433997
  2. Cathepsin X (CTSX) is involved in early tumorigenesis and in the stabilization of tumor cell formation in colorectal cancer. PMID: 25442015
  3. The significant association of cathepsin X with survival in a group of patients who received no chemotherapy and the absence of this association in the group who received chemotherapy, suggest the possible predictive value for response to chemotherapy. PMID: 24725597
  4. Suggest CTSZ rs34069356 polymorphism is not associated with pulmonary tuberculosis in a sample Iranian population. PMID: 23827504
  5. We show that sequential cleavage of C-terminal amino acids from the beta(2) cytoplasmic tail of LFA-1, by CatX, enhances binding of the adaptor protein talin to LFA-1 and triggers formation of the latter's high-affinity form PMID: 21454358
  6. cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma PMID: 21966391
  7. cathepsin X deficiency leads to accelerated cellular senescence and consequently to diminished cellular proliferation and migration/invasion implying a potential role of cathepsin X in bypassing cellular senescence. PMID: 21616554
  8. Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility. PMID: 21368909
  9. associated with tuberculosis in a Ugandan household contact study PMID: 21354459
  10. Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin. PMID: 21310951
  11. These results show that cathepsin P, in contrast to other mammalian cathepsins, has a restricted catalytic specificity. PMID: 15680921
  12. the extracellular function of cathepsin X may include binding to integrins thereby modulating the attachment of migrating cells to ECM components [Cathepsin X] PMID: 17065156
  13. unlikely that CTSZ gene plays a major role in tuberculosis susceptibility in African populations PMID: 18420963

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Subcellular Location
Lysosome.
Protein Families
Peptidase C1 family
Tissue Specificity
Widely expressed.
Database Links

HGNC: 2547

OMIM: 603169

KEGG: hsa:1522

STRING: 9606.ENSP00000217131

UniGene: Hs.252549

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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