Cd82 Antibody

Datasheet

Code	CSB-PA004961LA01MO
Size	US$166
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Image	Western blot All lanes: Cd82 antibody at 2µg/ml Lane 1: Jurkat whole cell lysate Lane 2: A549 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 30 kDa Observed band size: 30 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Mus musculus (Mouse) Cd82 Polyclonal antibody

Uniprot No.

P40237

Target Names

Cd82

Alternative Names

Cd82 antibody; Kai1CD82 antigen antibody; C33 antigen antibody; IA4 antibody; Inducible membrane protein R2 antibody; Metastasis suppressor Kangai-1 homolog antibody; CD antigen CD82 antibody

Raised in

Rabbit

Species Reactivity

Mouse, Human

Immunogen

Recombinant Mouse CD82 antigen protein (111-227AA)

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

The Cd82 Antibody (Product code: CSB-PA004961LA01MO) is Non-conjugated. For Cd82 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA004961LB01MO	Cd82 Antibody, HRP conjugated	ELISA
FITC	CSB-PA004961LC01MO	Cd82 Antibody, FITC conjugated
Biotin	CSB-PA004961LD01MO	Cd82 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway.

Gene References into Functions

The CD82 is a functional surface marker of long-term repopulating hematopoietic stem cells (LT-HSCs) that maintains quiescence through interaction with DARC-expressing macrophages in the bone marrow stem cell niche. PMID: 26996598
Loss of Kai1 expression is associated with neoplasm metastasis. PMID: 23401136
The synergistic effects of CD82 and GM3 or GM2/GM3 ganglioside on EGFR expression and phosphorylation and cMet activation are responsible for CD82 inhibition of EGF- and HGF-dependent cell motility and migration of Hepa1-6 cells. PMID: 23968914
the CD82 tetraspanin is specifically recruited to pathogen-containing phagosomes prior to fusion with lysosomes. PMID: 21149584
KAI1 has a role in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase PMID: 20089858
Hypoxia-dependent induction of KAI1 was directly mediated by hypoxia-inducible factor-1alpha binding on the promoter, which subsequently caused increased recruitment of RNA polymerase II for transcriptional activation. PMID: 20123085
An antibody to this protein that can specifically detect murine Kai1/CD82, should be useful in addressing the mechanism of action of Kai1 in metastatic suppression. PMID: 16372335
gp78 promotes sarcoma metastasis by targeting KAI1 for degradation PMID: 18037895
The transgenic adenocarcinoma of mouse prostate model encompasses androgen depletion independent sublines with increased tumorigenicity and invasiveness. All showed downregulation in tumor suppressor, E-cadherin, and metastatis suppressor, KAI-1. PMID: 18247402

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

Tetraspanin (TM4SF) family

Tissue Specificity

Highest expression in the spleen and the kidney. Low expression in skeletal muscle and in the heart.

Database Links

KEGG: mmu:12521

STRING: 10090.ENSMUSP00000028644

UniGene: Mm.4261

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Related pathways

p53 signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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