DAO Antibody

Code CSB-PA006494LA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: HepG2 whole cell lysate
    All lanes: DAO antibody at 7.4µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 40 kDa
    Observed band size: 40 kDa

  • IHC image of CSB-PA006494LA01HU diluted at 1:500 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DAO Polyclonal antibody
Uniprot No.
Target Names
DAO
Alternative Names
D-amino-acid oxidase antibody; DAAO antibody; DAMOX antibody; DAO antibody; DAO1 antibody; EC 1.4.3.3 antibody; MGC35381 antibody; OXDA antibody; OXDA_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human D-amino-acid oxidase protein (1-347AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The DAO Antibody (Product code: CSB-PA006494LA01HU) is Non-conjugated. For DAO Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA006494LB01HU DAO Antibody, HRP conjugated ELISA
FITC CSB-PA006494LC01HU DAO Antibody, FITC conjugated
Biotin CSB-PA006494LD01HU DAO Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:500-1:1000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.
Gene References into Functions
  1. The combination of IL10 and DAO SNPs in a multivariate model did not alter the OR values. PMID: 28750137
  2. The mutant G allele of the C2029G DAO polymorphism was significantly more frequent in patients with migraine (P=.044). The OR of migraine for carriers of the mutant G allele of DAO compared to wild-type homozygous women was 1.6 (95% CI, 1.1-2.1). PMID: 27130307
  3. The study provides significant evidence for epistatic interactions among DAOA and DAO gene in the development of schizophrenia. These results provide additional evidence and indicate that the DAOA gene and DAOA-DAO gene-gene interactions might play a role for schizophrenia in a Taiwanese sample. PMID: 28285246
  4. pLG72 interacts with neosynthesized d-amino acid oxidase (hDAAO), promoting its inactivation and degradation. In this work, we used low-resolution techniques to characterize the surface topology of the hDAAO-pLG72 complex. PMID: 27400736
  5. lower levels predispose to disease exacerbation after fish intake in chronic urticaria patients PMID: 25982580
  6. The DAO gene was a susceptibility gene for schizophrenia and the genomic region between intron 1 and intron 8 may harbor functional genetic variants, which may influence the mRNA expression of DAO and neurocognitive functions in schizophrenia. PMID: 26986737
  7. In the brain, the concentration of D-serine stored in cells is defined by the activity of D-amino acid oxidase. PMID: 24256253
  8. Accumulation of d-serine contributes to an ALS pathogenesis, and DAO might be a common therapeutic target for ALS. PMID: 24085347
  9. Data suggest that neuronal DAAO is a long-lived protein: peroxisomal fraction of DAAO is degraded via lysosomal/endosomal pathway, whereas cytosolic fraction of DAAO is ubiquitinated and targeted to proteasome pathway. PMID: 24237903
  10. Data suggest that acyclovir (ACV) can serve as an active site probe to study the structural basis of temperature-induced conformational changes of d-Amino acid oxidase (DAO). PMID: 23859606
  11. The results suggest that DAO, which is involved in the N-methyl-d-aspartate receptor regulation, signaling and glutamate metabolism, is the master gene of the genetic associations and interactions underlying schizophrenia. PMID: 23555897
  12. study suggests that NMDA receptor-mediated signalling genes, DAO, PPP3CC, DTNBP1 might be involved in schizophrenia pathogenic mechanisms related to gender PMID: 23497497
  13. Data indicate that the protein aggregation due to the expression of the G331V d-amino acid oxidase (hDAAO) variant affects cell viability. PMID: 23219954
  14. The DAO polymorphism rs10156191 which causes impaired metabolism of circulating histamine is associated with the clinical response in crossed-hypersensitivity to NSAIDs and could be used as a biomarker of response. PMID: 23152756
  15. The distribution pattern of D-amino-acid oxidase gene and protein expression in the central nervous system is inversely correlated with D-serine content and distribution. (Review) PMID: 22865246
  16. D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects. PMID: 22802136
  17. A significant 3 way interaction between G72, DAAO and diagnosis is detected in the right middle temporal gyrus (after family-wise error correction), accounting for 8.5% of the individual variance in activation. PMID: 22239582
  18. Genetic polymorphisms in DAO are associated with reduced prepulse inhibition and worse performance in working memory tasks and a personality pattern characterized by attenuated anxiety. PMID: 21471957
  19. Data suggest that newly synthesized D-amino acid oxidase colocalizes and interacts with pLG72 which appears to be exposed on the external membrane of mitochondria. PMID: 21679769
  20. The rs3918347 allele nucleotide polymorphism of DAAO is associated with schizophrenia in Chinese. PMID: 20855273
  21. results suggest that genetic variation in DAAO has a significant impact on both regional activation and functional connectivity PMID: 21421061
  22. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. PMID: 21700703
  23. Data describe the the effects on human D-amino acid oxidase conformation and stability of the substrate D-serine, the FAD cofactor, and two inhibitors (benzoate and chlorpromazine. PMID: 20521334
  24. This study supported the hypothesis that DAO plays a role in schizophrenia, possibly in a gender-dependent manner in Koreans. PMID: 20483168
  25. The results of this study showed that DAO does not have an apparent degree of association with Japanese schizophrenia. PMID: 20178891
  26. Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase PMID: 20368421
  27. increased hippocampal DAAO expression in schizophrenia; could be responsible for a decrease in local D-serine levels leading to a NMDA-receptor hypofunction that is hypothesized to play a major role in the pathophysiology of schizophrenia PMID: 19823762
  28. results suggest that an increase in DAO expression in parts of the brain is involved in aberrant D-amino acid metabolism, may be a potential therapeutic target for schizophrenia PMID: 19685198
  29. Creatinine (CTN) was found to inhibit D-amino acid oxidase in uremia PMID: 12053066
  30. The association of both DAAO and a new gene G72 from 13q34 with schizophrenia together with activation of DAAO activity by a G72 protein product points to the involvement of this N-methyl-d-aspartate receptor regulation pathway in schizophrenia. PMID: 12364586
  31. DAAO was associated with schizophrenia, but not with bipolar disorder PMID: 14966479
  32. This study indicates that the DAAO gene may play a significant role in the etiology of schizophrenia in the Han Chinese. PMID: 15464270
  33. the human enzyme is a stable homodimer even in the apoprotein form and weakly binds the cofactor in the free form. PMID: 16616139
  34. We found elevated cerebellar DAAO activities in post-mortem brain samples from schizophrenic versus normal individuals. PMID: 16828464
  35. Crystal structure of human D-amino acid oxidase. PMID: 17088322
  36. The genes D-Amino-Acid Oxidase is regulate the glutamate neurotransmission in schizophrenia. PMID: 17250995
  37. might exert gene-specific modulating effects on schizophrenia endophenotypes at the population level PMID: 17336946
  38. evidence for epistatic interaction between the associated SNPs at DAOActivator and D-amino acid oxidase genes in contributing to schizophrenia risk PMID: 17492767
  39. Data suggest that the D-amino acid oxidase activator (DAOA/G30) locus, but not D-amino acid oxidase, may play a role in the pathophysiology of schizophrenia. PMID: 17627036
  40. significant associations between the rs3918346 and rs3825251 SNPs of the DAO gene and boys with autism spectrum disorders PMID: 17629951
  41. Polymorphisms are not associated with homicidal behavior in korean schizophrenics. PMID: 17728673
  42. These data suggest a potential role for DAO in susceptibility to depressive symptoms in schizophrenia, but a more general role for DAO in affective disorders cannot be excluded. PMID: 17890006
  43. Some support for the individual involvement of DAO and G72(DAOA)/G30 in the etiology of bipolar disorder. PMID: 18165970
  44. a decrease in the synaptic concentration of d-serine as the result of an anomalous increase in hDAAO activity related to hypoexpression of pLG72 may represent a molecular mechanism by which hDAAO and pLG72 are involved in schizophrenia susceptibility PMID: 18544534
  45. DAO activity and expression are increased in schizophrenia, but are not related to DAO or G72/G30 genotype PMID: 18560437
  46. Flavin-Adenine Dinucleotide binding only slightly increases the stability of human DAAO to denaturation by urea or temperature. PMID: 19309736
  47. present Scandinavian results do not verify previous associations between the analyzed DTNBP1, NRG1, DAO, DAOA, and GRM3 gene polymorphisms and schizophrenia PMID: 19439994
  48. The present association of dysbindin SNPs with negative symptoms and DAO SNPs with anxiety and depression is a replication of earlier findings and strengthens the hypothesis of a genetic association in schizophrenia. PMID: 19729970

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Involvement in disease
Schizophrenia (SCZD)
Subcellular Location
Peroxisome.
Protein Families
DAMOX/DASOX family
Database Links

HGNC: 2671

OMIM: 124050

KEGG: hsa:1610

STRING: 9606.ENSP00000228476

UniGene: Hs.113227

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