DDA1 Antibody

1. surveyed the spectrum of G protein coupling of dDA1 and Damb, and we confirmed that both receptors can couple to Gs to stimulate cAMP synthesis PMID: 29166600
2. The results indicate that DDA1 promotes lung cancer progression, potentially through promoting cyclins and cell cycle progression. PMID: 28211159
3. Data indicate that DET1- and DDB1-associated protein 1 (DDA1)-mediated tumor progression is associated with the activation of the NF-kappa B (NFkappaB)/COP9 signalosome 2(CSN2)/glycogen synthase kinase3beta (GSK3beta) pathway. PMID: 26942699
4. the c-Abl non-receptor kinase phosphorylates DDB1 at residue Tyr-316 to recruit a small regulatory protein, DDA1, leading to increased substrate ubiquitination PMID: 28087699
5. PCIA1 gene expression correlates with tumor formation, invasion and metastasis PMID: 17557237
6. Cells depleted of Dda1 spontaneously accumulated double-stranded DNA breaks in a similar way to Cul4A-, Cul4B- or Wdr23-depleted cells, indicating that Dda1 interacts physically and functionally with cullin-RING E3 ligases complexes. PMID: 19295130

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HGNC: 28360

KEGG: hsa:79016

STRING: 9606.ENSP00000352928

UniGene: Hs.466154