DDA1 Antibody

Datasheet

Code	CSB-PA880116LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Rat liver tissue, Mouse liver tissue All lanes: DDA1 antibody at 2.8μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 12 kDa Observed band size: 12 kDa Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA880116LA01HU at dilution of 1:100 Immunofluorescent analysis of PC-3 cells using CSB-PA880116LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DDA1 Polyclonal antibody

Uniprot No.

Q9BW61

Target Names

DDA1

Alternative Names

C19orf58 antibody; Cross immune reaction antigen PCIA1 antibody; DDA1 antibody; DDA1_HUMAN antibody; DET1 and DDB1 associated 1 antibody; DET1 and DDB1 associated protein 1 antibody; DET1- and DDB1-associated protein 1 antibody; MGC2594 antibody; PCIA-1 antibody; PCIA1 antibody; Placenta cross immune reaction antigen 1 antibody; Placenta cross-immune reaction antigen 1 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Human DET1- and DDB1-associated protein 1 protein (1-102AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DDA1 Antibody (Product code: CSB-PA880116LA01HU) is Non-conjugated. For DDA1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA880116LB01HU	DDA1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA880116LC01HU	DDA1 Antibody, FITC conjugated
Biotin	CSB-PA880116LD01HU	DDA1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. In the DCX complexes, acts as a scaffolding subunit required to stabilize the complex.

Gene References into Functions

surveyed the spectrum of G protein coupling of dDA1 and Damb, and we confirmed that both receptors can couple to Gs to stimulate cAMP synthesis PMID: 29166600
The results indicate that DDA1 promotes lung cancer progression, potentially through promoting cyclins and cell cycle progression. PMID: 28211159
Data indicate that DET1- and DDB1-associated protein 1 (DDA1)-mediated tumor progression is associated with the activation of the NF-kappa B (NFkappaB)/COP9 signalosome 2(CSN2)/glycogen synthase kinase3beta (GSK3beta) pathway. PMID: 26942699
the c-Abl non-receptor kinase phosphorylates DDB1 at residue Tyr-316 to recruit a small regulatory protein, DDA1, leading to increased substrate ubiquitination PMID: 28087699
PCIA1 gene expression correlates with tumor formation, invasion and metastasis PMID: 17557237
Cells depleted of Dda1 spontaneously accumulated double-stranded DNA breaks in a similar way to Cul4A-, Cul4B- or Wdr23-depleted cells, indicating that Dda1 interacts physically and functionally with cullin-RING E3 ligases complexes. PMID: 19295130

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Protein Families

DDA1 family

Database Links

HGNC: 28360

KEGG: hsa:79016

STRING: 9606.ENSP00000352928

UniGene: Hs.466154

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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