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| Code | CSB-PA006594GA01HU |
| Size | US$685 How to order? |
| Have Questions? | Leave a Message or Start an on-line Chat |
| Uniprot No. | P39656 |
| Target Names | DDOST |
| Alternative Names | DDOST; KIAA0115; OST48; OK/SW-cl.45; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; DDOST 48 kDa subunit; Oligosaccharyl transferase 48 kDa subunit |
| Raised in | Rabbit |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Human DDOST |
| Immunogen Species | Homo sapiens (Human) |
| Isotype | IgG |
| Purification Method | Antigen Affinity purified |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Tested Applications | ELISA,WB |
| Protocols | ELISA Protocol Western Blotting(WB) Protocol |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function |
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation.; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Required for the assembly of both SST3A- and SS3B-containing OST complexes.
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| Gene References into Functions |
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| Involvement in disease | Congenital disorder of glycosylation 1R (CDG1R) |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. |
| Protein Families | DDOST 48 kDa subunit family |
| Database Links |
HGNC: 2728 OMIM: 602202 KEGG: hsa:1650 STRING: 9606.ENSP00000364188 UniGene: Hs.523145 |
