DDX19B Antibody

Code CSB-PA006610GA01HU
Size US$685
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Product Details

Uniprot No. Q9UMR2
Target Names DDX19B
Alternative Names ATP-dependent RNA helicase DDX19B antibody; DBP5 antibody; Dbp5; yeast; homolog of antibody; DD19B_HUMAN antibody; DDX19 antibody; DDX19B antibody; DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B antibody; DEAD box protein 19B antibody; DEAD box RNA helicase DEAD5 antibody; DEAD-box protein 5 antibody; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (Dbp5; yeast; homolog) antibody; DEAD/H BOX 19 antibody; helicase DEAD5 antibody; RNAh antibody; TDBP antibody; yeast Dbp5 homolog antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human DDX19B
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.
Gene References into Functions
  1. These results imply that DBP5, GLE1 and IP6 have a conserved and individual function in the cytoplasmic mRNA expression. Variations in phenotype are due to the difference in each function of DBP5, GLE1 and IPPK in intracellular mRNA metabolism. PMID: 29746542
  2. DDX19 interacts with pre-termination complexes (preTCs) in a nucleotide-dependent manner. Furthermore, DDX19 increases the efficiency of termination complex (TC) formation and the peptide release in the presence of eukaryotic release factors. DDX19 also stabilizes ribosome complexes with translation elongation factors eEF1 and eEF2. PMID: 28180304
  3. Ddx19 is an RNA export factor required for nuclear import of the SRF coactivator MKL1 PMID: 25585691
  4. Dbp5, Gle1-IP6 and Nup159: a working model for mRNP export. PMID: 22064466
  5. identification and characterization of a gene coding a novel isoform PMID: 12219940
  6. Using in vitro assays, the authors demonstrate that NUP214 decreases both the RNA binding and ATPase activities of DBP5. PMID: 19219046
  7. Results describe the crystal structures of human DDX19, a DEXD/H-box protein, in its open and closed cleft conformations. PMID: 19244245

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Subcellular Location Cytoplasm. Nucleus, nucleoplasm.
Protein Families DEAD box helicase family, DDX19/DBP5 subfamily
Database Links

HGNC: 2742

OMIM: 605812

KEGG: hsa:11269

STRING: 9606.ENSP00000288071

UniGene: Hs.221761

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