DEFB104A Antibody

Datasheet

Code	CSB-PA840974LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA840974LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA840974LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DEFB104A Polyclonal antibody

Uniprot No.

Q8WTQ1

Target Names

DEFB104A

Alternative Names

BD 4 antibody; BD-4 antibody; BD4 antibody; beta 104 antibody; beta 4 Defensin antibody; Beta defensin 4 antibody; Beta-defensin 104 antibody; Beta-defensin 4 antibody; D104A_HUMAN antibody; DEFB-4 antibody; DEFB104B antibody; Defensin antibody; Defensin beta 104 antibody; Defensin beta 4 precursor antibody; hBD 4 antibody; hBD-4 antibody; hBD4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Beta-defensin 104 protein (23-72AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The DEFB104A Antibody (Product code: CSB-PA840974LA01HU) is Non-conjugated. For DEFB104A Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA840974LB01HU	DEFB104A Antibody, HRP conjugated	ELISA
FITC	CSB-PA840974LC01HU	DEFB104A Antibody, FITC conjugated
Biotin	CSB-PA840974LD01HU	DEFB104A Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.

Gene References into Functions

Beta-defensin 104 displays antimicrobial activity against S. carnosus, E. coli, S. cerevisiae, and P. aeruginosa (strong). PMID: 11481241
TFF3 activated the epithelial cells in culture to produce beta defensins 2 (hBD2) and beta defensins 4 PMID: 23198942
Data suggest an activation of b-defensin-4 induction, in human knee meniscus by the osteoarthritis inflammatory process as a result of an endogenous antibiotic defense mechanism accompanied by an intrinsic effort of tissue remodeling. PMID: 21879330
Our results suggest that copy number variation of DEFB4 may not contribute to the pathogenesis of Behcet's disease. PMID: 21385545
Analysis of the DEFB4 promoter region shows remarkably high density of sequence variabilities. PMID: 20445567
The variations in the genes encoding human beta-defensin-1 and -2 may be associated with the risk of severe acute pancreatitis. PMID: 20720450
Data show that beta-defensin cluster (DEFB4, DEFB103 and DEFB104) varied between 2 and 9 copies per genome, and high copy numbers (>4) were underrepresented among patients, suggesting that increased copy numbers could protect from CD. PMID: 20483368
We report here the application of small ubiquitin-related modifier (SUMO) fusion technology to the expression and purification of cationic antibacterial peptide hBD4. PMID: 20526896
This study demonstrates, the involvement of NOD1 and DEFB4 in direct killing of Helicobacter pylori bacteria by epithelial cells and confirms the importance of NOD1 in host defence mechanisms against cagPAI(+)Helicobacter pylori infection. PMID: 20039881
The mRNA level of the beta defensin 4 did not differ significantly between the two subgroups. PMID: 20128731
elevated DEFB4 copy number is a risk factor for Crohn's disease PMID: 19809410
There is an association of four common DEFB104 haplotypes with the risk of prostate cancer in two independent patient cohorts. PMID: 18515986

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Subcellular Location

Secreted.

Protein Families

Beta-defensin family

Tissue Specificity

High expression in the testis. Gastric antrum exhibited relatively high levels. A lower expression is observed in uterus and neutrophils thyroid gland, lung, and kidney. No detectable expression in other tissues tested.

Database Links

HGNC: 18115

KEGG: hsa:107984148

STRING: 9606.ENSP00000322191

UniGene: Hs.559507

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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