DEFB104A Antibody, HRP conjugated

Code CSB-PA840974LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DEFB104A Polyclonal antibody
Uniprot No.
Target Names
DEFB104A
Alternative Names
BD 4 antibody; BD-4 antibody; BD4 antibody; beta 104 antibody; beta 4 Defensin antibody; Beta defensin 4 antibody; Beta-defensin 104 antibody; Beta-defensin 4 antibody; D104A_HUMAN antibody; DEFB-4 antibody; DEFB104B antibody; Defensin antibody; Defensin beta 104 antibody; Defensin beta 4 precursor antibody; hBD 4 antibody; hBD-4 antibody; hBD4 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Beta-defensin 104 protein (23-72AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.
Gene References into Functions
  1. Beta-defensin 104 displays antimicrobial activity against S. carnosus, E. coli, S. cerevisiae, and P. aeruginosa (strong). PMID: 11481241
  2. TFF3 activated the epithelial cells in culture to produce beta defensins 2 (hBD2) and beta defensins 4 PMID: 23198942
  3. Data suggest an activation of b-defensin-4 induction, in human knee meniscus by the osteoarthritis inflammatory process as a result of an endogenous antibiotic defense mechanism accompanied by an intrinsic effort of tissue remodeling. PMID: 21879330
  4. Our results suggest that copy number variation of DEFB4 may not contribute to the pathogenesis of Behcet's disease. PMID: 21385545
  5. Analysis of the DEFB4 promoter region shows remarkably high density of sequence variabilities. PMID: 20445567
  6. The variations in the genes encoding human beta-defensin-1 and -2 may be associated with the risk of severe acute pancreatitis. PMID: 20720450
  7. Data show that beta-defensin cluster (DEFB4, DEFB103 and DEFB104) varied between 2 and 9 copies per genome, and high copy numbers (>4) were underrepresented among patients, suggesting that increased copy numbers could protect from CD. PMID: 20483368
  8. We report here the application of small ubiquitin-related modifier (SUMO) fusion technology to the expression and purification of cationic antibacterial peptide hBD4. PMID: 20526896
  9. This study demonstrates, the involvement of NOD1 and DEFB4 in direct killing of Helicobacter pylori bacteria by epithelial cells and confirms the importance of NOD1 in host defence mechanisms against cagPAI(+)Helicobacter pylori infection. PMID: 20039881
  10. The mRNA level of the beta defensin 4 did not differ significantly between the two subgroups. PMID: 20128731
  11. elevated DEFB4 copy number is a risk factor for Crohn's disease PMID: 19809410
  12. There is an association of four common DEFB104 haplotypes with the risk of prostate cancer in two independent patient cohorts. PMID: 18515986

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Subcellular Location
Secreted.
Protein Families
Beta-defensin family
Tissue Specificity
High expression in the testis. Gastric antrum exhibited relatively high levels. A lower expression is observed in uterus and neutrophils thyroid gland, lung, and kidney. No detectable expression in other tissues tested.
Database Links

HGNC: 18115

KEGG: hsa:107984148

STRING: 9606.ENSP00000322191

UniGene: Hs.559507

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