Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Gene References into Functions
These findings suggested that the down-regulated REIC expression might be involved in lung carcinogenesis due to its promoter methylation PMID: 29341059
the results indicate that TNFalpha downregulates REIC/Dkk3 expression in normal skin keratinocytes. PMID: 29512745
These results show that miR-25-3p has intracellular and extracellular oncogenic functions as well as clinicopathological relevance in osteosarcoma, indicating its potential as a novel diagnostic and therapeutic tool for the clinical management of this disease. PMID: 29674765
DKK3 might contribute to cellular proliferation, invasion, migration, and tumor cell survival in head and neck/oral squamous cell carcinoma cells through a mechanism other than the canonical Wnt signaling pathway, which might be attributed to PI3K-Akt signaling PMID: 28470144
this study demonstrated the anti-glioma effect of Ad-SGE-REIC, which may represent a promising strategy for the treatment of malignant glioma. PMID: 27625116
DKK3 is a novel and promising molecular target for keloid treatment. PMID: 28458155
This report demonstrates that GATA4 promotes oncogenesis by inhibiting miR125b-dependent suppression of DKK3 expression. This GATA4/miR125b/DKK3 axis may be a major regulator of growth, migration, invasion, and survival in hepatoma cells. PMID: 27788486
dickkopf-3 (Dkk-3) is a tumor suppressor gene that is downregulated in various cancers. PMID: 28168749
Study shows a reduced expression of DKK3 in adrenocortical carcinoma potentially contributing to adrenal dedifferentiation and/or progression of malignancy. PMID: 28249601
Low DKK3 expression is associated with gastric cancer. PMID: 28218426
studies decoding the underlying molecular mechanisms of DKK3-mediated effects may help to identify novel targeted therapies for this clinically highly relevant breast cancer subtype PMID: 27467270
REIC/Dkk-3 could be involved early in squamous cell carcinoma development and have inhibitory effect on the development of SCC PMID: 27354306
Administration of DKK3 protein and peripheral blood mononuclear cell transplantation synergistically enhanced anticancer immunological effects against pancreatic cancer cells. PMID: 26643412
Study showed that DKK3 promotes cell survival during oxidative stress by suppressing XDH expression, thereby abrogating excess reactive oxygen species accumulation and subsequent apoptosis. PMID: 28299863
High DKK3 expression is associated with malignant progression of oral submucous fibrosis. PMID: 27959428
The data indicated that Dkk3 has a novel role in modulating macropinocytotic and autophagic pathways, a distinct function other than a Wnt antagonist. PMID: 27827955
we observed Dickkopf-related protein 3 (DKK3) as a direct target of miR-25 in vitro. Upregulation of DKK3 partially attenuated the oncogenic effect of miR-25 on melanoma cells. Ectopic expression of miR-25 in melanoma cells induced beta-catenin accumulation in nuclear and inhibited TCF4 (T cell factor 4) activity, as well as the expression of c-Myc and Cyclin D1. PMID: 27801786
in situ Ad-REIC((REIC)/Dkk-3 gene) gene therapy is expected to realize a new-generation cancer vaccine via anticancer immune activation with DC and tumor antigen-specific CTL expansion. PMID: 26836118
Loss of DKK3 expression in dysplastic/advanced stage of oral submucous fibrosis may imply a high risk of progression to oral cancer. PMID: 27349317
Dkk3 is upregulated in osteoarthritis and may have a protective effect on cartilage integrity by preventing proteoglycan loss and helping to restore OA-relevant signaling pathway activity. PMID: 26687825
A decreased risk of lung cancer was found for the genotype combination of DKK3 and sFRP4. PMID: 26457595
Data indicate that Dickkopf-related protein 3 (DKK3) improved gemcitabine therapeutic effect through inducing apoptosis and regulating beta-catenin/epithelial-mesenchymal transition (EMT) signalling in pancreatic cancer cell. PMID: 26395974
these data suggest that downregulation of tubular beta-catenin signaling induced by Dkk-3 has a detrimental role in chronic proteinuria, partially through the increase in apoptosis. PMID: 27010856
Down-regulation of Dkk3 is associated with recurrence in Endometrioid Adenocarcinoma. PMID: 26397159
beta2M-mediated VEGFR-2/Akt/mTOR phosphorylation and tumor angiogenesis was significantly suppressed by over-expression of DKK-3. PMID: 26278164
Observations highlight a role for Dkk-3 in modulating TGF-beta/MMP signals in the prostate and prostate cancer. PMID: 26503968
first report documenting that DKK3 polymorphisms are not only associated with prostate cancer but also related to prostate cancer-related factors. PMID: 26689513
REIC/Dkk-3 is a naturally circulating serum protein, the upregulation REIC/Dkk-3 protein expression could be a promising option for cancer therapy PMID: 25823913
we propose that Dickkopf-related protein-3 (Dkk-3) might be a novel Amyloid-beta (Abeta) associated protein PMID: 26119087
Dkk-3 has a tumor-suppressive function and a proapoptotic effect, inducing apoptosis through mitochondrial and Fas death receptor pathways in human mucinous ovarian cancer MCAS cells. PMID: 25514350
Epigenetic downregulation of DKK3 leads to docetaxel resistance in human nonsmall cell lung cancer (NSCLC) cells. PMID: 25760729
reactivation of Dkk3 enhances the chemosensitivity to cisplatin in cisplatinresistant lung adenocarcinoma cell lines PMID: 25573172
Suggest that DKK3 may be important in mediating invasion in esophageal adenocarcinoma. PMID: 26093488
DKK3 downregulation across all MB subgroups may be due to epigenetic mechanisms, in particular, through chromatin condensation. PMID: 23567267
Loss of DKK3 protein expression was significantly associated with poor survival in patients with gastric cancer and was strongly correlated with the TNM stage. PMID: 25604390
Loss of DKK3 expression is associated with glioblastoma. PMID: 25301448
The results suggested that the lack of affinity between human DKK3 and human LRP5/6 results from: i) insertion of the 7 amino acids, and ii) P258 in human DKK3. PMID: 24743782
Loss of REIC expression is associated withnon-small cell lung cancer. PMID: 24498395
data indicates that miR-92b directly regulate cell proliferation and apoptosis by targeting DKK3 and act as prognostic factors for glioma patients PMID: 24325785
Dkk3 levels corrected to platelet count showed higher levels in polycythemia vera patients than normal controls. Elevated Dkk3c level could possibly correlate to platelet activation in polycythemia vera patients and increased Dkk3 release. PMID: 24309205
DKK3 gene is a potential tumor suppressor gene in thyroid cancer, and aberrant promoter methylation is an important mechanism for its downregulation, which may play a role in the tumorigenesis and aggressiveness of papillary thyroid carcinoma. PMID: 23702469
elevated Dkk-3 in the stroma of the diseased prostate presumably regulates stromal remodeling by enhancing proliferation and differentiation of stromal cells and contributing to the angiogenic switch observed in BPH and prostate cancer. PMID: 23765731
These data demonstrated that Dkk-3 expression in OSCC was different than that in adenocarcinomas. Dkk-3 may possess an oncogenic function that is independent of Wnt signaling. PMID: 23354949
We developed a protocol to generate smooth muscle cells from pluripotent stem cells through a dickkopf 3 signaling pathway, useful for generating tissue-engineered vessels. PMID: 23529184
Data identifies Dkk-3 and SMAD4 as potential target genes of miR-183 in prostate cancer. PMID: 23538390
Decreased DKK3 expression was associated with advanced International Federation of Gynecology and Obstetrics clinical stages and was predictive of lower disease-free survival in patients with cervical squamous cell carcinoma. PMID: 23154266
aberrant expression of REIC might play some role in growth and lymph node metastasis of gastric carcinoma by suppressing growth, migration and invasion and/or by inducing apoptosis PMID: 22421143
Dkk3 gene expression is frequently downregulated in endometrial cancer, and is associated with poor prognostic clinicopathologic markers. Results identify a role for Dkk3 as a tumor suppressor in EC, affecting both proliferation and invasiveness. PMID: 22555103
Dkk-3 overexpression induced apoptosis in human colon cancer possibly through the mitochondrial pathway. Dkk-3 may be involved in the Wnt/beta-catenin signaling pathways in colon cancer. PMID: 22529687
Five bladder cancer cell lines among six cell lines examined were resistant to adenovirus-Dkk-3. PMID: 22076283
Show More
Hide All
Subcellular Location
Secreted.
Protein Families
Dickkopf family
Tissue Specificity
Highest expression in heart, brain, and spinal cord.