DNAJC3 Antibody, Biotin conjugated

1. DNAJC3 p.H238N is likely to be a variant causing diabetes. PMID: 29767246
2. p58IPK is a general inhibitor of the eIF2alpha kinases in that it also interacts with GCN2. Thus forced overexpression of cytoplasmic p58 delays eIF2alpha phosphorylation, suppresses GCN2 phosphorylation and prolongs protein synthesis PMID: 25329545
3. Loss-of-function DNAJC3 mutations lead to a monogenic, recessive form of diabetes mellitus in humans. PMID: 25466870
4. p58(IPK) suppresses coxsackievirus B3-induced apoptosis through selective activation of PI3K/Akt pathway that requires activation of ATF6a and subsequently upregulates mitofusin 2. PMID: 24134518
5. interplay between p38 phosphorylation and p58(IPK) upregulation has key roles in modulating ERp29-induced cell-growth arrest and survival PMID: 22064321
6. the crystal structure of human P58(IPK) PMID: 21799829
7. Coxsackievirus B3 infection induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1. PMID: 20554776
8. Spleen cells from transgenic mice overexpressing (Hu)PKR were studied and compared to those from wild-type mice after drug treatment. Dact-treated spleen cells were resistant to apoptosis; ConA-treated cells had decreased cell division. PMID: 12034040
9. P58(IPK) is an important component of a negative feedback loop used by the cell to inhibit eIF2alpha signaling, and thus attenuate the unfolded protein response. PMID: 12601012
10. The study demonstrates that P58(IPK) inhibits endoplasmic reticulum (ER) stress and plays an important role in maintaining balance and stability of the ER in human retinal capillary endothelial cells. PMID: 18568130

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HGNC: 9439

OMIM: 601184

KEGG: hsa:5611

STRING: 9606.ENSP00000365991

UniGene: Hs.59214