DOK3 Antibody, Biotin conjugated

Code CSB-PA007019LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DOK3 Polyclonal antibody
Uniprot No.
Target Names
DOK3
Alternative Names
Docking protein 3 antibody; DOK 3 antibody; DOK Like Protein antibody; Dok3 antibody; DOK3_HUMAN antibody; DOKL Pending antibody; Downstream of tyrosine kinase 3 antibody; p62 DOK Like Protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Docking protein 3 protein (1-146AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function.
Gene References into Functions
  1. Mutations in DOK3 gene is associated with prostate cancer PMID: 26585945
  2. DOK2 and DOK3 expression was significantly reduced in HTLV-1-infected T cells. PMID: 27265473
  3. The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters PMID: 23223229
  4. absence of DOK3 increases LPS signaling, contributing to LPS-induced tolerance. Thus, DOK3 plays a role in TLR signaling during both naive and endotoxin-induced tolerant conditions PMID: 22761938
  5. Identification of DOK genes as lung tumor suppressors. PMID: 20139980
  6. The novel platelet adapter Dok-3 is tyrosine phosphorylated in an Src kinase-independent manner downstream of alphaIIbbeta3 in human platelets, leading to an interaction with Grb2 and SHIP-1. PMID: 19682241
  7. findings indicate that Dok-3 sequesters Grb2 from Shc and inhibits the Ras-Erk pathway downstream of PTKs PMID: 16436051

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Subcellular Location
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein Families
DOK family, Type A subfamily
Tissue Specificity
Expressed in spleen.
Database Links

HGNC: 24583

OMIM: 611435

KEGG: hsa:79930

STRING: 9606.ENSP00000349727

UniGene: Hs.720849

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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