DOK3

DOK3 encodes the docking protein 3. Also known as downstream of tyrosine kinase 3, DOK3 is an adaptor protein. It functions mainly by binding to phosphorylated tyrosine residues on activated receptors or receptor-associated kinases, regulating signal transduction. It is involved in multiple signal pathways such as the PI3K - AKT pathway, which is crucial for cell survival, growth, and metabolism.
Abnormal expression of DOK3 is associated with several diseases, including certain types of cancers and immune - related disorders. In drug development, research is exploring ways to target DOK3 and its related pathways. Some pre - clinical studies aim to develop agents that can modulate DOK3 activity to treat these associated diseases.