DUSP11 Antibody, Biotin conjugated

Datasheet

Code	CSB-PA007240LD01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) DUSP11 Polyclonal antibody

Uniprot No.

O75319

Target Names

DUSP11

Alternative Names

DUSP11 antibody; PIR1RNA/RNP complex-1-interacting phosphatase antibody; EC 3.1.3.- antibody; Dual specificity protein phosphatase 11 antibody; Phosphatase that interacts with RNA/RNP complex 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human RNA/RNP complex-1-interacting phosphatase protein (105-377AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.

Gene References into Functions

Results implicate DUSP11 as an important component of XRN-mediated restriction of hepatitis C virus replication. PMID: 30038017
DUSP11 regulates host and viral non-coding RNAs in mammalian cells. PMID: 28296624
PIR gene expression is highly dependent on the expression of HR-HPV E6 and E7 oncoproteins HPV-positive cell lines. PMID: 29118270
DUSP11 converts the 5' triphosphate of miRNA precursors to a 5' monophosphate, promoting loading of derivative 5p miRNAs into Argonaute proteins via a Dicer-coupled 5' monophosphate-dependent strand selection mechanism. PMID: 27798849
the atomic structure of a catalytically inactive mutant (C152S) of the human PIR1 phosphatase core (PIR1-core, residues 29-205), refined at 1.20 A resolution. PMID: 24447265
results suggest that DUSP11 contributes to p53-dependent inhibition of cell proliferation and that it might be involved in regulating RNA splicing through SAM68 PMID: 19120688

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Subcellular Location

Nucleus. Nucleus speckle.

Protein Families

Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily

Database Links

HGNC: 3066

OMIM: 603092

KEGG: hsa:8446

STRING: 9606.ENSP00000272444

UniGene: Hs.14611

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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