DUSP11 Antibody

Code CSB-PA007240LA01HU
Size US$299
  • Western Blot
    Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate, PC3 whole cell lysate
    All lanes: DUSP11 antibody at 1:2000
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 39, 26 kDa
    Observed band size: 39 kDa
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) DUSP11 Polyclonal antibody
Uniprot No. O75319
Target Names DUSP11
Alternative Names DUSP11 antibody; PIR1RNA/RNP complex-1-interacting phosphatase antibody; EC 3.1.3.- antibody; Dual specificity protein phosphatase 11 antibody; Phosphatase that interacts with RNA/RNP complex 1 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human RNA/RNP complex-1-interacting phosphatase protein (105-377AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.
Gene References into Functions
  1. Results implicate DUSP11 as an important component of XRN-mediated restriction of hepatitis C virus replication. PMID: 30038017
  2. DUSP11 regulates host and viral non-coding RNAs in mammalian cells. PMID: 28296624
  3. PIR gene expression is highly dependent on the expression of HR-HPV E6 and E7 oncoproteins HPV-positive cell lines. PMID: 29118270
  4. DUSP11 converts the 5' triphosphate of miRNA precursors to a 5' monophosphate, promoting loading of derivative 5p miRNAs into Argonaute proteins via a Dicer-coupled 5' monophosphate-dependent strand selection mechanism. PMID: 27798849
  5. the atomic structure of a catalytically inactive mutant (C152S) of the human PIR1 phosphatase core (PIR1-core, residues 29-205), refined at 1.20 A resolution. PMID: 24447265
  6. results suggest that DUSP11 contributes to p53-dependent inhibition of cell proliferation and that it might be involved in regulating RNA splicing through SAM68 PMID: 19120688

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Subcellular Location Nucleus, Nucleus speckle
Protein Families Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Database Links

HGNC: 3066

OMIM: 603092

KEGG: hsa:8446

STRING: 9606.ENSP00000272444

UniGene: Hs.14611


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