DUSP11 Antibody

Code CSB-PA833161
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA833161(DUSP11 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
DUSP11
Alternative Names
DUSP11 antibody; PIR1RNA/RNP complex-1-interacting phosphatase antibody; EC 3.1.3.- antibody; Dual specificity protein phosphatase 11 antibody; Phosphatase that interacts with RNA/RNP complex 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Full length fusion protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:10000
IHC 1:30-1:150
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.
Gene References into Functions
  1. Results implicate DUSP11 as an important component of XRN-mediated restriction of hepatitis C virus replication. PMID: 30038017
  2. DUSP11 regulates host and viral non-coding RNAs in mammalian cells. PMID: 28296624
  3. PIR gene expression is highly dependent on the expression of HR-HPV E6 and E7 oncoproteins HPV-positive cell lines. PMID: 29118270
  4. DUSP11 converts the 5' triphosphate of miRNA precursors to a 5' monophosphate, promoting loading of derivative 5p miRNAs into Argonaute proteins via a Dicer-coupled 5' monophosphate-dependent strand selection mechanism. PMID: 27798849
  5. the atomic structure of a catalytically inactive mutant (C152S) of the human PIR1 phosphatase core (PIR1-core, residues 29-205), refined at 1.20 A resolution. PMID: 24447265
  6. results suggest that DUSP11 contributes to p53-dependent inhibition of cell proliferation and that it might be involved in regulating RNA splicing through SAM68 PMID: 19120688

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Subcellular Location
Nucleus. Nucleus speckle.
Protein Families
Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Database Links

HGNC: 3066

OMIM: 603092

KEGG: hsa:8446

STRING: 9606.ENSP00000272444

UniGene: Hs.14611

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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